Trial reportScientific reports2021
Alterations in reward network functional connectivity are associated with increased food addiction in obese individuals.
Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 30 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
30 citing papers in PubMed, 1 synthesis or guideline pooled it.
- Biopsychosocial and Environmental Factors That Impact Brain-Gut-Microbiome Interactions in Obesity.Clinical gastroenterology and hepatology : the official clinical practice journal of the American Gastroenterological Association · 2026Pooled it
- Brain functional connectivity patterns associated with adiposity in schizophrenia.Psychiatry research. Neuroimaging · 2026Article
- Cognitive reappraisal of food and emotion cues involves common and unique neural contributions.bioRxiv : the preprint server for biology · 2026Article
- Multimodal Neuroimaging of Obesity: From Structural-Functional Mechanisms to Precision Interventions.Brain sciences · 2025Review
- Emotional Eating, Impulsivity, and Affective Temperaments in a Sample of Obese Candidates for Bariatric Surgery: Which Linkage?Brain sciences · 2025Article
- The brainstem reticular formation pivots abnormal neural transmission in the course of Anorexia Nervosa.Journal of neural transmission (Vienna, Austria : 1996) · 2025Review
- Examining maladaptive eating behaviors and psychological difficulties among women with compulsive eating and obesity: a latent profile analysis.Journal of eating disorders · 2025Article
- The Role of Artificial Intelligence in Obesity Risk Prediction and Management: Approaches, Insights, and Recommendations.Medicina (Kaunas, Lithuania) · 2025Review
- The Impact of Acute Aerobic Exercise on General and Food-Related Inhibitory Function Among Young Adults with Obesity: An Event-Related Potential (ERP) Study.Brain sciences · 2025Article
- From attributes to value: Neural correlates of a front-of-package label on food decision-making - An fMRI study.PloS one · 2025Article
- Questioning the validity of food addiction: a critical review.Frontiers in behavioral neuroscience · 2025Review
- The Effect of Physical Activity Interventions on Executive Function in Overweight and Obese Adults: A Systematic Review.Biomedicines · 2024Review
- Early life adversity impacts alterations in brain structure and food addiction in individuals with high BMI.Scientific reports · 2024Article
- AgRP neuron activity promotes associations between sensory and nutritive signals to guide flavor preference.Molecular metabolism · 2023Article
- Acupuncture modulates the functional connectivity among the subcortical nucleus and fronto-parietal network in adolescents with internet addiction.Brain and behavior · 2023Article
- Brain-gut microbiome profile of neuroticism predicts food addiction in obesity: A transdiagnostic approach.Progress in neuro-psychopharmacology & biological psychiatry · 2023Article
- Excess BMI in early adolescence adversely impacts maturating functional circuits supporting high-level cognition and their structural correlates.International journal of obesity (2005) · 2023Article
- Improved psychosocial measures associated with physical activity may be explained by alterations in brain-gut microbiome signatures.Scientific reports · 2023Article
- Reduced Striatal Dopamine Transporter Availability and Heightened Response to Natural and Pharmacological Stimulation in CCK-1R-Deficient Obese Rats.International journal of molecular sciences · 2023Article
- Priorities for research on neuromodulatory subcortical systems in Alzheimer's disease: Position paper from the NSS PIA of ISTAART.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2023Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
10 authors.
Funding
Abstract
Functional neuroimaging studies in obesity have identified alterations in the connectivity within the reward network leading to decreased homeostatic control of ingestive behavior. However, the neural mechanisms underlying sex differences in the prevalence of food addiction in obesity is unknown. The aim of the study was to identify functional connectivity alterations associated with: (1) Food addiction, (2) Sex- differences in food addiction, (3) Ingestive behaviors. 150 participants (females: N = 103, males: N = 47; food addiction: N = 40, no food addiction: N = 110) with high BMI ≥ 25 kg/m
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.