Evidence map›Paper›PMID 33564012›Full record

Trial reportScientific reports2021

Relevance of pathogenicity prediction tools in human RYR1 variants of unknown significance.

Kerstin Hoppe, Karin Jurkat-Rott, Stefanie Kranepuhl, Scott Wearing, Sebastian Heiderich, Sonja Merlak, Werner Klingler

Open access · goldAbstract readClinical Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Scientific reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
0.7field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed, 11 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. How Functional Genomics Can Keep Pace With VUS Identification.Frontiers in cardiovascular medicine · 2022
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 5 institutions in 2 countries.

Kerstin HoppeDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapie, University of Wuerzburg, Oberduerrbacher Straße 6, 97080, Wuerzburg, Germany.
Karin Jurkat-RottDivision of Experimental Anesthesiology, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Stefanie KranepuhlDepartment of Anesthesiology, Intensive Care Medicine and Pain Therapy, University of Frankfurt, Goethe University, Theodor-Stern-Kai 7, 60590, Frankfurt, Germany.
Scott WearingInstitute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, 4059, Australia.
Sebastian HeiderichClinic of Anesthesiology and Intensive Care Medicine, Hannover Medical School, Hannover, Germany.
Sonja MerlakDivision of Experimental Anesthesiology, University Medical Center Ulm, Albert-Einstein-Allee 23, 89081, Ulm, Germany.
Werner KlinglerInstitute of Health and Biomedical Innovation, Queensland University of Technology, 60 Musk Avenue, Kelvin Grove, 4059, Australia. Werner.Klingler@uni-ulm.de.
Goethe University Frankfurt · DEMedizinische Hochschule Hannover · DEQueensland University of Technology · AUTechnical University of Munich · DEUniversity of Würzburg · DE

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Malignant hyperthermia (MH) is a pharmacogenetic disorder of skeletal muscle metabolism characterized by generalized muscle rigidity, increased body temperature, rhabdomyolysis, hyperkalemia and severe metabolic acidosis. The underlying mechanism of MH involves excessive Ca

Indexed as

Databases, Nucleic AcidExonsGenetic VariationAdultCalcium Channels, L-TypeFemaleHumansMaleMalignant HyperthermiaMiddle AgedPredictive Value of TestsRetrospective StudiesRyanodine Receptor Calcium Release ChannelCACNA1S protein, humanCalcium Channels, L-TypeRyanodine Receptor Calcium Release ChannelRYR1 protein, human

Identifiers

PMID33564012
PMCPMC7873245
OpenAlexW3127332149

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.