Evidence map›Paper›PMID 33563981›Full record

ArticleNature communications2021

L1 retrotransposons exploit RNA m

Sung-Yeon Hwang, Hyunchul Jung, Seyoung Mun, Sungwon Lee, Kiwon Park, S Chan Baek, Hyungseok C Moon, Hyewon Kim, Baekgyu Kim, Yongkuk Choi and 10 more

Open access · goldAbstract read
In one paragraph

Article in Nature communications, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 39 papers.

0numbers the graph read from it
0cells of the map it votes in
39citing papers in PubMed
3.2field-weighted citation impact, top 7% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

39 citing papers in PubMed, 55 citations in OpenAlex.

  1. Review
  2. Nuclear mNature chemical biology · 2026
    Article
  3. Article
  4. Review
  5. Article
  6. Review
  7. Review
  8. Article
  9. Interpretability-guided RNA NCommunications biology · 2025
    Article
  10. Review
  11. Article
  12. Article
  13. SomaticiScience · 2025
    Article
  14. Article
  15. From the genome's perspective: Bearing somatic retrotransposition to leverage the regulatory potential of L1 RNAs.BioEssays : news and reviews in molecular, cellular and developmental biology · 2025
    Review
  16. Review
  17. Review
  18. Article
  19. Review
  20. RNA mCellular and molecular life sciences : CMLS · 2024
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 4 countries.

Sung-Yeon HwangCenter for RNA Research, Institute for Basic Science, Seoul, Republic of Korea.
Hyunchul JungDepartment of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea.
Seyoung MunDepartment of Nanobiomedical Science, Dankook University, Cheonan, Republic of Korea.
Sungwon LeeCenter for RNA Research, Institute for Basic Science, Seoul, Republic of Korea.
Kiwon ParkCenter for RNA Research, Institute for Basic Science, Seoul, Republic of Korea.
S Chan BaekCenter for RNA Research, Institute for Basic Science, Seoul, Republic of Korea.
Hyungseok C MoonDepartment of Physics and Astronomy, Seoul National University, Seoul, Republic of Korea.
Hyewon KimCenter for RNA Research, Institute for Basic Science, Seoul, Republic of Korea.
Baekgyu KimCenter for RNA Research, Institute for Basic Science, Seoul, Republic of Korea.
Yongkuk ChoiCenter for RNA Research, Institute for Basic Science, Seoul, Republic of Korea.
Young-Hyun GoDepartment of Pharmacy, Seoul National University, Seoul, Republic of Korea.
Wanxiangfu TangDepartment of Biological Sciences, Brock University, St. Catharines, ON, Canada.
Jongsu ChoiDr. von Hauner Children's Hospital, Ludwig-Maximilians-University of Munich, Munich, Germany.ORCID 0000-0001-5007-7469
Jung Kyoon ChoiDepartment of Bio and Brain Engineering, KAIST, Daejeon, Republic of Korea.ORCID 0000-0003-2077-8947
Hyuk-Jin ChaDepartment of Pharmacy, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0001-9277-2662
Hye Yoon ParkDepartment of Physics and Astronomy, Seoul National University, Seoul, Republic of Korea.ORCID 0000-0003-4704-8178
Ping LiangDepartment of Biological Sciences, Brock University, St. Catharines, ON, Canada.ORCID 0000-0003-4423-0636
V Narry KimCenter for RNA Research, Institute for Basic Science, Seoul, Republic of Korea.ORCID 0000-0002-3213-4965
Kyudong HanDKU-Theragen institute for NGS analysis (DTiNa), Cheonan, Republic of Korea. kyudong.han@gmail.com.
Kwangseog AhnCenter for RNA Research, Institute for Basic Science, Seoul, Republic of Korea. ksahn@snu.ac.kr.
Seoul National University · KRKorea Advanced Institute of Science and Technology · KRBrock University · CATheragen · KR

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

L1 retrotransposons can pose a threat to genome integrity. The host has evolved to restrict L1 replication. However, mechanisms underlying L1 propagation out of the host surveillance remains unclear. Here, we propose an evolutionary survival strategy of L1, which exploits RNA m

Indexed as

Evolution, Molecular5' Untranslated RegionsAdenosineAlkB Homolog 5, RNA DemethylaseAnimalsHeLa CellsHumansLong Interspersed Nucleotide ElementsMethylationMethyltransferasesPrimatesProtein BiosynthesisRibonucleoproteinsRNA5' Untranslated RegionsAdenosineALKBH5 protein, humanAlkB Homolog 5, RNA DemethylaseMethyltransferasesMETTL3 protein, humanN-methyladenosineRibonucleoproteinsRNA

Identifiers

PMID33563981
PMCPMC7873242
OpenAlexW3128502844

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.