ArticleJournal of neurology, neurosurgery, and psychiatry2021
Quality of life in isolated dystonia: non-motor manifestations matter.
Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 35 papers.
What it found
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The trial behind it
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Who cites it
35 citing papers in PubMed, 52 citations in OpenAlex.
- Efficacy and Safety of DaxibotulinumtoxinA for Injection in Cervical Dystonia: ASPEN-1 Phase 3 Randomized Controlled Trial.Neurology · 2024Trial
- Pridinol treatment in cervical dystonia: improvement of non-motor symptoms.Annals of medicine · 2026Article
- DaxibotulinumtoxinA for Injection in Adults with Cervical Dystonia: Clinical Insights from a Real-World Early Experience Program.Movement disorders clinical practice · 2026Observational
- Psychiatric Comorbidity, Tic Severity and Quality of Life in Adults with Tourette's Syndrome.Movement disorders clinical practice · 2026Article
- Investigating Sleep Concerns in Cervical Dystonia.Movement disorders clinical practice · 2026Article
- Transcriptomic disruption and hypoactivity in DYT-SGCE medial ganglionic eminence-patterned inhibitory neurons.Brain : a journal of neurology · 2026Article
- Risk of Cervical Spine Complications in Individuals with Cervical Dystonia Treated with Botulinum Toxin Therapy.Tremor and other hyperkinetic movements (New York, N.Y.) · 2026Article
- Prevalence and treatment effects on non-motor symptoms in cervical dystonia: A systematic review and meta-analysis.Clinical parkinsonism & related disorders · 2026Review
- Cerebellar motor and non-motor contributions to dystonia pathophysiology and treatment.Dystonia (Lausanne, Switzerland) · 2026Article
- Beyond the Neck: Long-Term Motor and Non-motor Outcomes of Pallidal DBS in Craniocervical Dystonia.Dystonia (Lausanne, Switzerland) · 2026Article
- GDF15 - A potential novel biomarker of cognitive impairment in cervical dystonia.Frontiers in neuroscience · 2026Article
- Development of a Patient-Centered Outcome Tool for Blepharospasm: A Stepwise Modified Delphi Study.Toxins · 2025Article
- Article
- Non-Motor Symptoms and Health-Related Quality of Life in Patients with Isolated Dystonia: A Cross-Sectional Study.Healthcare (Basel, Switzerland) · 2025Article
- Diagnostic accuracy of screening tools for depression and anxiety in cervical dystonia.Parkinsonism & related disorders · 2025Observational
- Depressive symptoms and quality of life in patients with benign essential blepharospasm under long-term therapy with botulinum toxin.Acta neurologica Belgica · 2025Article
- Neurorehabilitation in Dystonia Care: Key Questions of Who Benefits, What Modalities, and When to Intervene.Dystonia (Lausanne, Switzerland) · 2025Article
- External Factors Modulating Pain and Pain-Related Functional Impairment in Cervical Dystonia.Movement disorders clinical practice · 2024Article
- Article
- Head movement dynamics in dystonia: a multi-centre retrospective study using visual perceptive deep learning.NPJ digital medicine · 2024Article
Corrections and comments
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Authors and funding
17 authors at 13 institutions in 4 countries.
Funding
Abstract
objectiveTo evaluate the relationship between health-related quality of life (HR-QoL) and both physical and psychiatric factors in a large, international, multicentre cohort of patients with isolated dystonia, the Dystonia Coalition.
methodsNatural history data from 603 patients with isolated dystonia (median age 57 years (IQR: 48 to 64 years), 67.0% women) were prospectively acquired and analysed. HR-QoL (RAND 36-Item Health Survey), severity of depressive symptoms, generalised anxiety (Hospital Anxiety and Depression Scale) and social anxiety (Liebowitz Social Anxiety Scale) were assessed. Dystonia severity (Burke-Fahn-Marsden Dystonia Rating Scale) and dystonic tremor were examined. Statistical predictors of HR-QoL were calculated using saturated path analysis.
resultsReduced HR-QoL was strongly associated with the degree of depressive symptoms and generalised and social anxiety (8/8 RAND 36 subscales, p≤0.001). Increased dystonia severity was associated with worse physical functioning, physical and emotional role functioning and social functioning (all p≤0.001). The presence of tremor correlated with worse physical functioning and pain (all p≤0.006). Younger age was associated with reduced emotional well-being and vitality (all p≤0.006). There were no HR-QoL differences between sexes.
conclusionHR-QoL in isolated dystonia is strongly associated with psychiatric and physical features. While current standard of care focus on motor aspects of dystonia, comprehensive care should address both physical and mental aspects of health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.