ArticleJournal of neurology, neurosurgery, and psychiatry2021
Sex differences for phenotype in pathologically defined dementia with Lewy bodies.
Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 36 papers, 3 of them syntheses that pooled it.
What it found
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The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
36 citing papers in PubMed, 3 syntheses or guidelines pooled it, 49 citations in OpenAlex.
- Sex differences inFrontiers in dementia · 2025Pooled it
- Orthostatic hypotension in dementia with Lewy bodies: a meta-analysis of prospective studies.Clinical autonomic research : official journal of the Clinical Autonomic Research Society · 2023Pooled it
- Sex differences in alpha-synucleinopathies: a systematic review.Frontiers in neurology · 2023Pooled it
- Activated microglial phenotypes in the hippocampal CA2 subfield are implicated in Lewy body disease progression.Acta neuropathologica · 2026Article
- Understanding the genetic imperfections of Lewy body dementia.Molecular neurodegeneration · 2026Review
- Proteomic analysis in Alzheimer's disease and other dementias: a focus on sex-specific differences.Alzheimer's research & therapy · 2026Article
- Sex differences for clinical presentations and co-pathologies in four-repeat tauopathies.Biology of sex differences · 2026Article
- Microglial reactivity in the hippocampal CA2 is associated with advanced neuronal α-synucleinopathy.bioRxiv : the preprint server for biology · 2026Article
- Sex differences for symptoms prior to dementia onset in people with Lewy body pathology compared to pure Alzheimer's disease pathology.Journal of Alzheimer's disease : JAD · 2026Article
- Sex Differences in Associations of Lewy Body Disease with Alzheimer's Disease and Cognitive Decline.Annals of neurology · 2025Article
- Towards optimizing the diagnosis of Lewy body dementia: Lessons from the NACC.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Sex and gender differences in Lewy body dementia: a narrative review.Equity neuroscience · 2025Article
- A Multi-Stakeholder Evaluation of a Walking Football Group for People with Dementia Developed in Partnership with a Premier League Club.Sports (Basel, Switzerland) · 2025Article
- X chromosome-wide association studies in neurological disorders: uncovering the hidden influence of the X chromosome.Frontiers in genetics · 2025Review
- Motor signs and incident dementia with Lewy bodies in older adults with mild cognitive impairment.Journal of the American Geriatrics Society · 2025Article
- Article
- What is the future for dementia with Lewy bodies?Journal of neurology · 2024Review
- LRRK2-Associated Parkinsonism With and WithoutmedRxiv : the preprint server for health sciences · 2024Article
- Differentiating Prodromal Dementia with Lewy Bodies from Prodromal Alzheimer's Disease: A Pragmatic Review for Clinicians.Neurology and therapy · 2024Article
- Grey matter networks in women and men with dementia with Lewy bodies.NPJ Parkinson's disease · 2024Article
Corrections and comments
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Authors and funding
4 authors at 1 institution in 1 country.
Funding
Abstract
introductionSex differences in dementia with Lewy bodies (DLB) have been reported in clinically defined cohorts; however, clinical diagnostic accuracy in DLB is suboptimal and phenotypic differences have not been assessed in pathologically confirmed participants.
methodsCore DLB features were compared across 55 women and 156 men with pathologically defined DLB in the National Alzheimer's Coordinating Center. These analyses were repeated for 55 women and 55 men matched for age, education and tau burden.
resultsIn the total sample, women died older, had fewer years of education, had higher tau burden but were less likely to be diagnosed with dementia and clinical DLB. In the matched sample, visual hallucinations continued to be less common in women, and fewer women met clinical DLB criteria. DISCUSSION: Sex impacts clinical manifestations of underlying pathologies in DLB. Despite similar underlying Lewy body pathology, women are less likely to manifest core DLB features and may be clinically underdiagnosed.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.