ArticleJournal of neurology, neurosurgery, and psychiatry2021
Predicting loss of independence and mortality in frontotemporal lobar degeneration syndromes.
Article in Journal of neurology, neurosurgery, and psychiatry, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 33 papers.
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Who cites it
33 citing papers in PubMed, 45 citations in OpenAlex.
- Behavioural and psychological symptom determinants of carer burden across clinical syndromes associated with frontotemporal lobar degeneration and Alzheimer's disease: a transdiagnostic analysis.Journal of neurology · 2026Article
- Behavior determines times to care home admission and death in semantic dementia: Insights from a cohort of 90 cases.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Article
- Prognostic factors of survival in corticobasal syndrome and corticobasal degeneration: A scoping review.Neurological sciences : official journal of the Italian Neurological Society and of the Italian Society of Clinical Neurophysiology · 2026Article
- Emerging directions in tauopathy research.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026Review
- The social dimension of apathy: evidence for a distinct domain from 11,243 individuals across health and neurocognitive disorders.Translational psychiatry · 2026Article
- Article
- Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration.Alzheimer's & dementia. Behavior & socioeconomics of aging · 2025Article
- Survival rates in frontotemporal dementia and Alzheimer's disease.Neurodegenerative disease management · 2025Article
- Functional Impairment in Behavioral Variant Frontotemporal Dementia: Cognitive, Behavioral, Personality, and Brain Perfusion Contributions.Journal of personalized medicine · 2025Article
- Cognitive and neuropsychiatric profiles distinguish atypical parkinsonian syndromes.Brain : a journal of neurology · 2025Article
- Higher neighborhood deprivation is associated with accelerated disease progression in behavioral-variant frontotemporal degeneration.medRxiv : the preprint server for health sciences · 2025Article
- Behavioural changes in frontotemporal dementia and their cognitive and neuroanatomical correlates.Brain : a journal of neurology · 2025Article
- GABAergic modulation of beta power enhances motor adaptation in frontotemporal lobar degeneration.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Decision cost hypersensitivity underlies Huntington's disease apathy.Brain : a journal of neurology · 2025Article
- The graded multidimensional geometry of phenotypic variation and progression in neurodegenerative syndromes.Brain : a journal of neurology · 2025Article
- Caregiver perspectives enable accurate diagnosis of neurodegenerative disease.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2025Article
- Self- versus caregiver-reported apathy across neurological disorders.Brain communications · 2025Article
- Noradrenergic therapies in neurodegenerative disease: from symptomatic to disease modifying therapy?Brain communications · 2025Review
- Clinical prognostic factors in progressive supranuclear palsy: Implications for clinical trials.Journal of Parkinson's disease · 2024Article
- Predictors of Care Home Admission and Survival Rate in Patients With Syndromes Associated With Frontotemporal Lobar Degeneration in Europe.Neurology · 2024Observational
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Authors and funding
11 authors at 2 institutions in 1 country.
Funding
Abstract
objectiveTo test the hypothesis that in syndromes associated with frontotemporal lobar degeneration, behavioural impairment predicts loss of functional independence and motor clinical features predict mortality, irrespective of diagnostic group.
methodsWe used a transdiagnostic approach to survival in an epidemiological cohort in the UK, testing the association between clinical features, independence and survival in patients with clinical diagnoses of behavioural variant frontotemporal dementia (bvFTD n=64), non-fluent variant primary progressive aphasia (nfvPPA n=36), semantic variant primary progressive aphasia (svPPA n=25), progressive supranuclear palsy (PSP n=101) and corticobasal syndrome (CBS n=68). A principal components analysis identified six dimensions of clinical features. Using Cox proportional hazards and logistic regression, we identified the association between each of these dimensions and both functionally independent survival (time from clinical assessment to care home admission) and absolute survival (time to death). Analyses adjusted for the covariates of age, gender and diagnostic group. Secondary analysis excluded specific diagnostic groups.
resultsBehavioural disturbance, including impulsivity and apathy, was associated with reduced functionally independent survival (OR 2.46, p<0.001), even if patients with bvFTD were removed from the analysis. Motor impairments were associated with reduced absolute survival, even if patients with PSP and CBS were removed from the analysis.
conclusionOur results can assist individualised prognostication and planning of disease-modifying trials, and they support a transdiagnostic approach to symptomatic treatment trials in patients with clinical syndromes associated with frontotemporal lobar degeneration.
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