Evidence map›Paper›PMID 33563788›Full record

ArticlemSystems2021

Sulfur Metabolites Play Key System-Level Roles in Modulating Denitrification.

Anne E Otwell, Alex V Carr, Erica L W Majumder, Maryann K Ruiz, Regina L Wilpiszeski, Linh T Hoang, Bill Webb, Serdar Turkarslan, Sean M Gibbons, Dwayne A Elias and 3 more

Open access · goldAbstract read
In one paragraph

Article in mSystems, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 8 papers.

0numbers the graph read from it
0cells of the map it votes in
8citing papers in PubMed
2.7field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

8 citing papers in PubMed, 28 citations in OpenAlex.

  1. Review
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  4. Draft genome sequence ofMicrobiology resource announcements · 2024
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 5 institutions in 1 country.

Anne E Otwell *Institute for Systems Biology, Seattle, Washington, USA.
Alex V Carr *Institute for Systems Biology, Seattle, Washington, USA.
Erica L W MajumderCenter for Metabolomics and Mass Spectrometry, Scripps Research Institute, La Jolla, California, USA.
Maryann K RuizInstitute for Systems Biology, Seattle, Washington, USA.
Regina L WilpiszeskiBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.
Linh T HoangCenter for Metabolomics and Mass Spectrometry, Scripps Research Institute, La Jolla, California, USA.
Bill WebbCenter for Metabolomics and Mass Spectrometry, Scripps Research Institute, La Jolla, California, USA.
Serdar TurkarslanInstitute for Systems Biology, Seattle, Washington, USA.
Sean M GibbonsInstitute for Systems Biology, Seattle, Washington, USA.ORCID https://orcid.org/0000-0002-8724-7916
Dwayne A EliasBiosciences Division, Oak Ridge National Laboratory, Oak Ridge, Tennessee, USA.ORCID https://orcid.org/0000-0002-4469-6391
David A StahlMolecular Engineering Sciences, University of Washington, Seattle, Washington, USA.
Gary SiuzdakCenter for Metabolomics and Mass Spectrometry, Scripps Research Institute, La Jolla, California, USA.
Nitin S BaligaInstitute for Systems Biology, Seattle, Washington, USA nitin.baliga@isbscience.org.ORCID https://orcid.org/0000-0001-9157-5974
University of Washington · USScripps Research Institute · USInstitute for Systems Biology · USOak Ridge National Laboratory · USPurchase College · US

Funding

Metabolomics Technologies to Advance Biomedical ResearchR35GM130385 · NIGMS · SCRIPPS RESEARCH INSTITUTE, THE · PI GARY E SIUZDAK · 2019 to 2026
$3.9M
NIGMS NIH HHS R35 GM130385
6 · The paper itself

Abstract

Competition between nitrate-reducing bacteria (NRB) and sulfate-reducing bacteria (SRB) for resources in anoxic environments is generally thought to be governed largely by thermodynamics. It is now recognized that intermediates of nitrogen and sulfur cycling (e.g., hydrogen sulfide, nitrite, etc.) can also directly impact NRB and SRB activities in freshwater, wastewater, and sediment and therefore may play important roles in competitive interactions. Here, through comparative transcriptomic and metabolomic analyses, we have uncovered mechanisms of hydrogen sulfide- and cysteine-mediated inhibition of nitrate respiratory growth for the NRB

Indexed as

cysteinedenitrificationenvironmental microbiologyhydrogen sulfidemetabolomicsmicrobial ecologynitrate-reducing bacteriasystems biologytranscriptomics

Identifiers

PMID33563788
PMCPMC7883540
OpenAlexW3127755105

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.