Evidence map›Paper›PMID 33563776›Full record

Observational studyOpen heart2021

Health-related quality of life 1-3 years post-myocardial infarction: its impact on prognosis.

Stuart Pocock, David B Brieger, Ruth Owen, Jiyan Chen, Mauricio G Cohen, Shaun Goodman, Christopher B Granger, José C Nicolau, Tabassome Simon, Dirk Westermann and 5 more

Registry-linked trialAbstract readMulticenter StudyObservational Study
PubMed Full text at PMC Publisher
In one paragraph

Observational study in Open heart, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT01866904 (TIGRIS), which is not on this map. Cited by 28 papers, 4 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
28citing papers in PubMed, 4 pooled it
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT01866904 terminatednot on this map

TIGRIS: Long-Term rIsk, Clinical manaGement and Healthcare Resource Utilization of Stable Coronary Artery dISease in Post Myocardial Infarction Patients

TypeobservationalSponsorAstraZenecaRan2013 to 2017Enrolled9,284ConditionsStable Coronary Artery Disease (CAD), Myocardial Infarction
3 · Its place in the literature

Who cites it

28 citing papers in PubMed, 4 syntheses or guidelines pooled it.

  1. Pooled it
  2. Pooled it
  3. Pooled it
  4. Pooled it
  5. Trial
  6. Trial
  7. Article
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Article
  14. Article
  15. Review
  16. Article
  17. Article
  18. Long-term all-cause mortality rate after ST-elevation myocardial infarction and its predictors: ST Elevation Myocardial Infarction Cohort in Isfahan Study.Journal of research in medical sciences : the official journal of Isfahan University of Medical Sciences · 2025
    Article
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

15 authors.

Stuart PocockMedical Statistics, London School of Hygiene & Tropical Medicine, London, UK Stuart.Pocock@lshtm.ac.uk.ORCID 0000-0003-2212-4007
David B BriegerCardiology, Concord Hospital, Concord, New South Wales, Australia.ORCID 0000-0001-6115-0326
Ruth OwenLondon School of Hygiene & Tropical Medicine, London, UK.
Jiyan ChenCardiology, Guangdong General Hospital, Guangzhou, Guangdong, China.
Mauricio G CohenCardiovascular Division, Department of Medicine, University of Miami Miller School of Medicine, Miami, Florida, USA.
Shaun GoodmanConsultant, Canadian Heart Research Centre, North York, Ontario, Canada.
Christopher B GrangerCardiac Care Unit, Duke University Medical Center, Durham, North Carolina, USA.
José C NicolauInstituto do Coração, Faculdade de Medicina da Universidade de São Paulo, São Paulo, Brazil.
Tabassome SimonDepartment of Clinical Pharmacology, Assistance Publique-Hôpitaux de Paris, Saint Antoine Hospital, Paris, France.ORCID 0000-0002-4550-0450
Dirk WestermannDepartment of General and Interventional Cardiology, University Heart Center Hamburg Eppendorf, Hamburg, Germany.ORCID 0000-0002-7542-1956
Satoshi YasudaCardiovascular Medicine, National Cerebral and Cardiovascular Center, Suita, Japan.
Katarina HedmanBioPharmaceuticals R&D, CVRM Biometrics, AstraZeneca, Gothenburg, Sweden.
Carl MellströmBioPharmaceuticals CVRM, AstraZeneca, Gothenburg, Sweden.
Karolina Andersson SundellBioPharmaceuticals Medical, CVRM Evidence, AstraZeneca, Gothenburg, Sweden.
Richard GrieveDepartment of Health Services Research and Policy, London School of Hygiene & Tropical Medicine, London, UK.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

objectiveTo assess associations of health-related quality of life (HRQoL) with patient profile, resource use, cardiovascular (CV) events and mortality in stable patients post-myocardial infarction (MI).

methodsThe global, prospective, observational TIGRIS Study enrolled 9126 patients 1-3 years post-MI. HRQoL was assessed at enrolment and 6-month intervals using the patient-reported EuroQol-5 dimension (EQ-5D) questionnaire, with scores anchored at 0 (worst possible) and 1 (perfect health). Resource use, CV events and mortality were recorded during 2-years' follow-up. Regression models estimated the associations of index score at enrolment with patient characteristics, resource use, CV events and mortality over 2-years' follow-up.

resultsAmong 8978 patients who completed the EQ-5D questionnaire, 52% reported 'some' or 'severe' problems on one or more health dimensions. Factors associated with a lower index score were: female sex, older age, obesity, smoking, higher heart rate, less formal education, presence of comorbidity (eg, angina, stroke), emergency room visit in the previous 6 months and non-ST-elevation MI as the index event. Compared with an index score of 1 at enrolment, a lower index score was associated with higher risk of all-cause death, with an adjusted rate ratio of 3.09 (95% CI 2.20 to 4.31), and of a CV event, with a rate ratio of 2.31 (95% CI 1.76 to 3.03). Patients with lower index score at enrolment had almost two times as many hospitalisations over 2-years' follow-up.

conclusionsClinicians managing patients post-acute coronary syndrome should recognise that a poorer HRQoL is clearly linked to risk of hospitalisations, major CV events and death. TRIAL REGISTRATION NUMBER: ClinicalTrials.gov Registry (NCT01866904) (https://clinicaltrials.gov).

Indexed as

ElectrocardiographyHealth StatusQuality of LifeRegistriesAgedAged, 80 and overFemaleFollow-Up StudiesHospitalizationHumansMaleMiddle AgedMyocardial InfarctionPrognosisProspective StudiesSurveys and Questionnairescoronary artery diseasemyocardial infarctionquality of healthcare

Identifiers

PMID33563776
PMCPMC7962722

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.