Observational studySaudi medical journal2021
Vitamin B12 deficiency in patients with type 2 diabetes mellitus using metformin and the associated factors in Saudi Arabia.
Observational study in Saudi medical journal, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 12 papers.
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Who cites it
12 citing papers in PubMed, 19 citations in OpenAlex.
- Exploring the risk of depression and suicide/self-injury in patients receiving GLP-1RAs combined with metformin versus GLP-1RA monotherapy: a real-word analysis of the FAERS database.Endocrine connections · 2026Article
- Letter to Editor: Comments on "Association of Vitamin B12 and Vitamin D Levels with Glycemic Control in Patients with Type 2 Diabetes Mellitus: Cross-Sectional Study".International journal of preventive medicine · 2026Article
- Evaluation of Vitamin B12 Deficiency Among Patients with Type 2 Diabetes Mellitus on Metformin at Hoima Regional Referral Hospital, Uganda.Diabetes, metabolic syndrome and obesity : targets and therapy · 2026Article
- Impact of Metformin Therapy on Vitamin B12 Levels in Patients With Type 2 Diabetes Mellitus.Endocrinology, diabetes & metabolism · 2025Article
- Article
- Metformin Use and Vitamin B12 Deficiency in People with Type 2 Diabetes. What Are the Risk Factors? A Mini-systematic Review.TouchREVIEWS in endocrinology · 2024Review
- Article
- Review
- Vitamin BIrish journal of medical science · 2024Review
- Diabetes mellitus research in Saudi Arabia: A bibliometric study (2010-2021).Journal of family medicine and primary care · 2023Review
- Is metformin a possible treatment for diabetic neuropathy?Journal of diabetes · 2022Review
- Association of vitamin B12 deficiency with metformin use in patients with type 2 diabetes treated in the largest tertiary care hospital in Qatar.Qatar medical journal · 2021Article
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Authors and funding
2 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
objectivesTo assess the presence of vitamin B12 deficiency among metformin users and associated factors in patients with type 2 diabetes mellitus.
methodsAn observational cross-sectional study was conducted with 307 diabetic patients in the primary health care centers at King Abdulaziz Medical City (KAMC), Riyadh, Saudi Arabia between October 2017 and January 2018. Face-to-face interviews were conducted with the participants, using a designed checklist.
resultsThe prevalence of vitamin B12 deficiency was (3.6%) and the majority of the sample had borderline B12 levels (66.1%). The vitamin B12 deficiency and borderline levels were strongly associated with the dose of metformin. Patients taking doses of metformin more than 1000 mg had lower levels of vitamin B12. The use of multivitamin and vitamin B complex was assessed, and it was found that there was a marked decrease in the prevalence of vitamin B12 deficiency in patients using vitamin B complex containing more than 200 mcg vitamin B12.
conclusionOur findings show a low prevalence of vitamin B12 deficiency in type 2 diabetic patients taking metformin. The majority of the sample had borderline deficiency; therefore, additional investigation and management are required.
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