Evidence map›Paper›PMID 33563725›Full record

ArticleThe Journal of neuroscience : the official journal of the Society for Neuroscience2021

Dorsal Raphe Dopamine Neurons Signal Motivational Salience Dependent on Internal State, Expectation, and Behavioral Context.

Jounhong Ryan Cho, Xinhong Chen, Anat Kahan, J Elliott Robinson, Daniel A Wagenaar, Viviana Gradinaru

Open access · bronzeAbstract read
In one paragraph

Article in The Journal of neuroscience : the official journal of the Society for Neuroscience, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 21 papers.

0numbers the graph read from it
0cells of the map it votes in
21citing papers in PubMed
3.7field-weighted citation impact, top 6% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

21 citing papers in PubMed, 57 citations in OpenAlex.

  1. Dorsal raphe tau pathology disrupts sleep-wake orchestration and sleep architecture in a sex-specific manner.Alzheimer's & dementia : the journal of the Alzheimer's Association · 2026
    Article
  2. Article
  3. Dorsal Raphe VIP Neurons Are Critical for Survival-Oriented Vigilance.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
  4. Review
  5. Review
  6. miRNA modules for precise, tunable control of gene expression.bioRxiv : the preprint server for biology · 2025
    Article
  7. Article
  8. Adenosine ABiological psychiatry · 2025
    Article
  9. Dorsal raphe to basolateral amygdala corticotropin-releasing factor circuit regulates cocaine-memory reconsolidation.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2024
    Article
  10. Article
  11. Pavlovian Fear Conditioning Is More than You Think It Is.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2023
    Article
  12. Article
  13. Article
  14. Article
  15. Article
  16. Spatiotemporal Control of Noradrenaline-Dependent Synaptic Transmission in Mouse Dorsal Raphe Serotonin Neurons.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022
    Article
  17. Aversive motivation and cognitive control.Neuroscience and biobehavioral reviews · 2022
    Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 1 institution in 1 country.

Jounhong Ryan ChoDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
Xinhong ChenDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.ORCID 0000-0003-0408-0813
Anat KahanDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
J Elliott RobinsonDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
Daniel A WagenaarDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125.
Viviana GradinaruDivision of Biology and Biological Engineering, California Institute of Technology, Pasadena, California 91125 viviana@caltech.edu.
California Institute of Technology · US

Funding

Time-Reversal Optical Focusing for Noninvasive OptogeneticsU01NS090577 · NINDS · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRADINARU, VIVIANA, YANG, CHANGHUEI · 2014 to 2016
$2.0M
Intact Circuit Assessment of Aging Dopamine Neurons vis Optogenetics and CLARITYR01AG047664 · NIA · CALIFORNIA INSTITUTE OF TECHNOLOGY · PI GRADINARU, VIVIANA · 2014 to 2018
$2.0M
NIA NIH HHS R01 AG047664NINDS NIH HHS U01 NS090577
6 · The paper itself

Abstract

The ability to recognize motivationally salient events and adaptively respond to them is critical for survival. Here, we tested whether dopamine (DA) neurons in the dorsal raphe nucleus (DRN) contribute to this process in both male and female mice. Population recordings of DRN

Indexed as

AnimalsDopaminergic NeuronsDorsal Raphe NucleusFemaleHabituation, PsychophysiologicLearningMaleMiceMice, TransgenicMicroscopy, Fluorescence, MultiphotonMotivationNeuronsPhotometrySignal Transductiondopaminedorsal raphe nucleusfiber photometryhead fixationmotivational saliencetwo-photon imaging

Identifiers

PMID33563725
PMCPMC8018733
OpenAlexW3127490885

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.