Evidence map›Paper›PMID 33563667›Full record

ArticleBMJ case reports2021

Seronegative Goodpasture's syndrome associated with organising pneumonia.

Ju Young Bae, Khalil Ian Hussein, Eric Leibert, Herbert M Archer

Open access · greenAbstract readCase Reports
In one paragraph

Article in BMJ case reports, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.4field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 3 citations in OpenAlex.

  1. Article
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Ju Young BaeInternal Medicine, Greenwich Hospital/Yale-New Haven Health, Greenwich, Connecticut, USA.
Khalil Ian HusseinMedical Education, Greenwich Hospital/Yale-New Haven Health, Greenwich, Connecticut, USA khalil.hussein@ynhh.org.ORCID http://orcid.org/0000-0001-9095-0103
Eric LeibertPulmonary/Critical Care, Greenwich Hospital/Yale-New Haven Health, Greenwich, Connecticut, USA.
Herbert M ArcherInternal Medicine, Greenwich Hospital/Yale-New Haven Health, Greenwich, Connecticut, USA.
Greenwich Hospital · US

Funding

Yale Clinical and Translational Science Award (U Component)UL1TR001863 · NCATS · YALE UNIVERSITY · PI John H. Krystal, LUCILA OHNO-MACHADO · 2016 to 2026
$102.9M
NCATS NIH HHS UL1 TR001863
6 · The paper itself

Abstract

Goodpasture's syndrome is a rare vasculitis associated with anti-glomerular basement membrane (anti-GBM) autoantibodies that target type IV collagen found in the basement membranes of glomeruli and alveoli. We present a case of a 79-year-old man with seronegative Goodpasture's syndrome with predominant respiratory symptoms and mild acute kidney injury that initially improved. Final diagnosis was made by immunofluorescent staining on open lung biopsy which also revealed concomitant organising pneumonia. The patient underwent treatment with corticosteroids, cyclophosphamide, haemodialysis and plasmapheresis. This was an atypical presentation wherein the patient only exhibited pulmonary symptoms early in the course of illness in the setting of negative anti-GBM antibody serum testing, which made diagnosis challenging. With this case, we emphasise that clinicians should have a high suspicion for Goodpasture's syndrome in the setting of unexplained severe pulmonary or renal disease despite negative anti-GBM antibody testing.

Indexed as

Acute Kidney InjuryAgedAnti-Glomerular Basement Membrane DiseaseAnti-Infective AgentsBiomarkersBronchoscopyDiagnosis, DifferentialFatal OutcomeHumansIntubation, IntratrachealMalePlasmapheresisPneumoniaRenal DialysisSteroidsAnti-Infective AgentsBiomarkersSteroidsacute renal failurecardiothoracic surgeryinterstitial lung diseasepathologyvasculitis

Identifiers

PMID33563667
PMCPMC7875259
OpenAlexW3127553057

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.