Evidence map›Paper›PMID 33563632›Full record

ArticleClinical cancer research : an official journal of the American Association for Cancer Research2021

Continuing to Broaden Eligibility Criteria to Make Clinical Trials More Representative and Inclusive: ASCO-Friends of Cancer Research Joint Research Statement.

Edward S Kim, Thomas S Uldrick, Caroline Schenkel, Suanna S Bruinooge, R Donald Harvey, Allison Magnuson, Alexander Spira, James L Wade, Mark D Stewart, Diana Merino Vega and 9 more

Abstract readLetter
In one paragraph

Article in Clinical cancer research : an official journal of the American Association for Cancer Research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.

0numbers the graph read from it
0cells of the map it votes in
65citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

65 citing papers in PubMed.

  1. Faith, Culture, and Cancer: A Qualitative Study Exploring Muslim Women's Perspectives on Clinical Trials in the United Kingdom.Health expectations : an international journal of public participation in health care and health policy · 2026
    Article
  2. Review
  3. Review
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  7. Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2026
    Article
  8. Scoping review of oncology clinical trials nursing: Roles, competencies, and evolving practice in cancer research.Canadian oncology nursing journal = Revue canadienne de nursing oncologique · 2026
    Article
  9. Article
  10. Eligibility criteria in phase 3 randomized controlled trials in gastric cancer.Gastric cancer : official journal of the International Gastric Cancer Association and the Japanese Gastric Cancer Association · 2025
    Article
  11. Article
  12. Article
  13. Article
  14. Totality of the Evidence: Optimizing Dosage Selection Strategies in Oncology.Journal of clinical oncology : official journal of the American Society of Clinical Oncology · 2025
    Article
  15. Article
  16. Article
  17. Article
  18. Article
  19. Article
  20. Article

5 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

19 authors.

Edward S Kim *City of Hope Orange County and National Medical Center, Los Angeles, California. edwkim@coh.org.
Thomas S Uldrick *Fred Hutchinson Cancer Research Center, Seattle, Washington.ORCID 0000-0001-6959-0924
Caroline SchenkelAmerican Society of Clinical Oncology, Alexandria, Virginia.ORCID 0000-0002-3613-8509
Suanna S BruinoogeAmerican Society of Clinical Oncology, Alexandria, Virginia.ORCID 0000-0002-9936-2719
R Donald HarveyEmory University School of Medicine, Atlanta, Georgia.ORCID 0000-0002-4217-1313
Allison MagnusonUniversity of Rochester, Rochester, New York.
Alexander SpiraVirginia Cancer Specialists PC, Fairfax, Virginia.
James L WadeCancer Care Specialists of Illinois, Decatur, Illinois.
Mark D StewartFriends of Cancer Research, Washington, DC.ORCID 0000-0002-4847-0736
Diana Merino VegaFriends of Cancer Research, Washington, DC.ORCID 0000-0002-6173-6957
Julia A BeaverU.S. Food and Drug Administration, Silver Spring, Maryland.
Andrea M DenicoffNational Cancer Institute, Bethesda, Maryland.
Gwynn IsonU.S. Food and Drug Administration, Silver Spring, Maryland.
S Percy IvyNational Cancer Institute, Bethesda, Maryland.
Suzanne GeorgeDana-Farber Cancer Institute, Boston, Massachusetts.
Raymond P PerezBristol-Myers Squibb, Lawrenceville, New Jersey.
Patricia A SpearsUNC Patient Advocates for Research Council, Raleigh, North Carolina.
William D TapMemorial Sloan Kettering Cancer Center, New York, New York.ORCID 0000-0001-7779-2796
Richard L SchilskyAmerican Society of Clinical Oncology, Alexandria, Virginia.ORCID 0000-0003-4474-4303

Funding

URCC NCORP Research BaseUG1CA189961 · NCI · UNIVERSITY OF ROCHESTER · PI Michelle C Janelsins, KAREN M. MUSTIAN · 2014 to 2026
$67.7M
Mitigating Cancer-Related Cognitive Dysfunction in Older Adults with Breast CancerK76AG064394 · NIA · UNIVERSITY OF ROCHESTER · PI MAGNUSON, ALLISON MARIAN · 2019 to 2023
$1.3M
NCI NIH HHS UG1 CA189961NIA NIH HHS K76 AG064394
6 · The paper itself

Abstract

purposeRestrictive clinical trial eligibility criteria (EC) limit the number of patients who can enroll and potentially benefit from protocol-driven, investigational treatment plans and reduce the generalizability of trial results to the broader population. Following publication of expert stakeholder recommendations for broadening EC in 2017, the American Society of Clinical Oncology (ASCO) and Friends of Cancer Research ( EXPERIMENTAL

designMultistakeholder working groups were appointed by an ASCO-

resultsThe four working groups, ASCO Board of Directors, and

conclusionsImplementation of the recommendations is intended to result in greater ease of determining patient eligibility. Increased opportunities for patient participation in research will help address longstanding underrepresentation of certain groups in clinical trials and produce evidence that is more informative for a broader patient population. More patients eligible will also likely speed clinical trial accrual.

Indexed as

Biomedical ResearchClinical Trials as TopicHumansMedical OncologyQuality of Health CareResearch Design

Identifiers

PMID33563632
PMCPMC12486295

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.