ArticleScience advances2021
Architecture and regulation of an enterobacterial cellulose secretion system.
Article in Science advances, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 18 papers.
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Who cites it
18 citing papers in PubMed.
- Free ammonia stress rewires microbial signaling networks and constrains metabolic cooperation in oxygenic photogranules.The ISME journal · 2026Article
- Article
- Revealing systematic changes in the transcriptome during the transition from exponential growth to stationary phase.mSystems · 2025Article
- Structural basis for synthase activation and cellulose modification in the E. coli Type II Bcs secretion system.Nature communications · 2024Article
- Thermothelomyces thermophilus exo- and endo-glucanases as tools for pathogenic E. coli biofilm degradation.Scientific reports · 2024Article
- Insights into phosphoethanolamine cellulose synthesis and secretion across the Gram-negative cell envelope.Nature communications · 2024Article
- Molecular insights into phosphoethanolamine cellulose formation and secretion.bioRxiv : the preprint server for biology · 2024Article
- Large Complexes: Cloning Strategy, Production, and Purification.Methods in molecular biology (Clifton, N.J.) · 2024Article
- Structures of theProceedings of the National Academy of Sciences of the United States of America · 2023Article
- The biofilm community resurfaces: new findings and post-pandemic progress.Journal of bacteriology · 2023Review
- The Crystal Structure of Tyrosinase fromBiomolecules · 2023Article
- Recent advances and perspectives in nucleotide second messenger signaling in bacteria.microLife · 2023Review
- Local signaling enhances output specificity of bacterial c-di-GMP signaling networks.microLife · 2023Review
- Bacterial crystalline cellulose secretion via a supramolecular BcsHD scaffold.Science advances · 2022Article
- Weaving of bacterial cellulose by the Bcs secretion systems.FEMS microbiology reviews · 2022Review
- Article
- Shigella flexneri Diguanylate Cyclases Regulate Virulence.Journal of bacteriology · 2021Article
- Regulation of Biofilm Exopolysaccharide Production by Cyclic Di-Guanosine Monophosphate.Frontiers in microbiology · 2021Review
Corrections and comments
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Authors and funding
5 authors.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Many free-living and pathogenic enterobacteria secrete biofilm-promoting cellulose using a multicomponent, envelope-embedded Bcs secretion system under the control of intracellular second messenger c-di-GMP. The molecular understanding of system assembly and cellulose secretion has been largely limited to the crystallographic studies of a distantly homologous BcsAB synthase tandem and a low-resolution reconstruction of an assembled macrocomplex that encompasses most of the inner membrane and cytosolic subunits and features an atypical layered architecture. Here, we present cryo-EM structures of the assembled Bcs macrocomplex, as well as multiple crystallographic snapshots of regulatory Bcs subcomplexes. The structural and functional data uncover the mechanism of asymmetric secretion system assembly and periplasmic crown polymerization and reveal unexpected subunit stoichiometry, multisite c-di-GMP recognition, and ATP-dependent regulation.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.