ArticleDiabetes2021
Exercise Training Promotes Sex-Specific Adaptations in Mouse Inguinal White Adipose Tissue.
Article in Diabetes, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 22 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
22 citing papers in PubMed, 34 citations in OpenAlex.
- Regular parental pre-mating exercise reduces offspring white adiposity and is associated with hypothalamic neurodevelopmental changes during lactation.Molecular metabolism · 2026Article
- Physical activity promotes gut adaptation, nutrient responsiveness, and sensitivity to gut peptides in male mice.EBioMedicine · 2026Article
- Advances in Adipose Tissue Biology.Endocrine reviews · 2026Review
- Obesity and Exercise: New Insights and Perspectives.Endocrine reviews · 2025Review
- Proteomics-based mechanism of HIIT regulation of hepatic metabolism in aging female rats.Biogerontology · 2025Article
- Type 2 Diabetes and Obesity Alter Exercise Training-Induced Transcriptional Adaptations to Subcutaneous White Adipose Tissue.bioRxiv : the preprint server for biology · 2025Article
- Can Exercise-Mediated Adipose Browning Provide an Alternative Explanation for the Obesity Paradox?International journal of molecular sciences · 2025Review
- Heterogeneity of extracellular vesicles in porcine myoblasts regulates adipocyte differentiation.Scientific reports · 2024Article
- Exercise training and cold exposure trigger distinct molecular adaptations to inguinal white adipose tissue.Cell reports · 2024Article
- Changes in the Expression of Inflammatory Genes Induced by Chronic Exercise in the Adipose Tissue: Differences by Sex.Sports (Basel, Switzerland) · 2024Article
- Sexual dimorphism and the multi-omic response to exercise training in rat subcutaneous white adipose tissue.Nature metabolism · 2024Article
- Review
- Exercise-induced crosstalk between immune cells and adipocytes in humans: Role of oncostatin-M.Cell reports. Medicine · 2024Article
- Exercise-induced regulation of adipose tissue.Current opinion in genetics & development · 2023Review
- The Sympathetic Innervation of Adipose Tissues: Regulation, Functions, and Plasticity.Comprehensive Physiology · 2023Article
- Differential remodeling of subcutaneous white and interscapular brown adipose tissue by long-term exercise training in aged obese female mice.Journal of physiology and biochemistry · 2023Article
- Exercise training remodels inguinal white adipose tissue through adaptations in innervation, vascularization, and the extracellular matrix.Cell reports · 2023Article
- Exercise-induced intertissue communication: adipose tissue and the heart.Current opinion in physiology · 2023Article
- Single-cell dissection of the obesity-exercise axis in adipose-muscle tissues implies a critical role for mesenchymal stem cells.Cell metabolism · 2022Article
- Distinct Effects of High-Fat and High-Phosphate Diet on Glucose Metabolism and the Response to Voluntary Exercise in Male Mice.Nutrients · 2022Article
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Authors and funding
14 authors at 2 institutions in 1 country.
Funding
Abstract
Recent studies demonstrate that adaptations to white adipose tissue (WAT) are important components of the beneficial effects of exercise training on metabolic health. Exercise training favorably alters the phenotype of subcutaneous inguinal WAT (iWAT) in male mice, including decreasing fat mass, improving mitochondrial function, inducing beiging, and stimulating the secretion of adipokines. In this study, we find that despite performing more voluntary wheel running compared with males, these adaptations do not occur in the iWAT of female mice. Consistent with sex-specific adaptations, we report that mRNA expression of androgen receptor coactivators is upregulated in iWAT from trained male mice and that testosterone treatment of primary adipocytes derived from the iWAT of male, but not female mice, phenocopies exercise-induced metabolic adaptations. Sex specificity also occurs in the secretome profile, as we identify cysteine-rich secretory protein 1 (
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.