Evidence map›Paper›PMID 33563243›Full record

ArticleBMC ophthalmology2021

Role of nicergoline in corneal wound healing in diabetic rats.

Amanda Lemos Barros Martins Portela, Rafael Neves Moreno, Maria Helena Madruga Lima Ribeiro, Fernanda Miguel de Andrade, Yale Viana Alves, Mônica Alves, Rodrigo Pessoa Cavalcanti Lira

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In one paragraph

Article in BMC ophthalmology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Amanda Lemos Barros Martins PortelaFederal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil. amandalbmportela@gmail.com.
Rafael Neves MorenoFederal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.
Maria Helena Madruga Lima RibeiroKeizo-Asami Immunopathology Laboratory (LIKA), Recife, Pernambuco, Brazil.
Fernanda Miguel de AndradeFederal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.
Yale Viana AlvesFederal University of Campina Grande (UFCG), Campina Grande, Paraíba, Brazil.
Mônica AlvesUniversity of Campinas (UNICAMP), Campinas, São Paulo, Brazil.
Rodrigo Pessoa Cavalcanti LiraFederal University of Pernambuco (UFPE), Recife, Pernambuco, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

backgroundTo investigate the effect of nicergoline on the rate of complete corneal ulcer reepithelialization (CCUR) in diabetic rats with diabetic keratopathy.

methodsForty-eight streptozotocin-induced diabetic rats were randomly divided into two groups. The experimental group (n = 24) received nicergoline (10 mg.kg

resultsWhen compared, 4 of the 24 rats (17%) in the placebo group and 12 of the 24 rats (50%) in the nicergoline group were found to have CCUR within 72 h (log-rank = 0.027). Cox regression analysis found no effect of the covariates blood glucose (P = 0.601) or weight (P = 0.322) on the corneal reepithelialization (survival) curve.

conclusionsNicergoline increased wound healing rates relative to placebo and may therefore be investigated as a treatment option in diabetic keratopathy.

Indexed as

Corneal InjuriesDiabetes Mellitus, ExperimentalEpithelium, CornealNicergolineAnimalsRatsWound HealingNicergolineCorneal epitheliumCorneal ulcerDiabetes mellitusDiabetic neuropathyNicergolineWound healing

Identifiers

PMID33563243
PMCPMC7871528

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.