ArticleProceedings. Biological sciences2021
Cutting across structural and transcriptomic scales translates time across the lifespan in humans and chimpanzees.
Article in Proceedings. Biological sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
19 citing papers in PubMed, 24 citations in OpenAlex.
- Human-specific morphoregulatory signatures in basal radial glia characterise neocortex evolution.Nature communications · 2026Article
- Cat brains age like humans: translating time shows pet cats live to be natural models for human aging.Biology open · 2026Article
- In silico genome transplants and the cis-regulatory basis of biodiversity.Trends in genetics : TIG · 2026Review
- Humans have a longer period of cortical maturation across depth and hierarchy than macaques.PLoS biology · 2025Article
- The evolution of infant-directed communication: Comparing vocal input across all great apes.Science advances · 2025Article
- From Circuits to Lifespan: Translating Mouse and Human Timelines with Neuroimaging-Based Tractography.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2025Article
- Translating time: Challenges, progress, and future directions.Brain research bulletin · 2025Review
- Flexible information-seeking in chimpanzees.Cognition · 2024Article
- The uniqueness of human vulnerability to brain aging in great ape evolution.Science advances · 2024Article
- From circuits to lifespan: translating mouse and human timelines with neuroimaging based tractography.bioRxiv : the preprint server for biology · 2024Article
- The coming decade of digital brain research: A vision for neuroscience at the intersection of technology and computing.Imaging neuroscience (Cambridge, Mass.) · 2024Article
- The evolution of human altriciality and brain development in comparative context.Nature ecology & evolution · 2024Article
- Systematic cortical thickness and curvature patterns in primates.NeuroImage · 2023Article
- Transcription, structure, and organoids translate time across the lifespan of humans and great apes.PNAS nexus · 2023Article
- Going beyond established model systems of Alzheimer's disease: companion animals provide novel insights into the neurobiology of aging.Communications biology · 2023Review
- From fossils to mind.Communications biology · 2023Review
- Tracing Modification to Cortical Circuits in Human and Nonhuman Primates from High-Resolution Tractography, Transcription, and Temporal Dimensions.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2022Article
- Brain Plasticity in Humans and Model Systems: Advances, Challenges, and Future Directions.International journal of molecular sciences · 2021Review
- Cutting across structural and transcriptomic scales translates time across the lifespan in humans and chimpanzees.Proceedings. Biological sciences · 2021Article
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1 author at 1 institution in 1 country.
Funding
Abstract
How the unique capacities of human cognition arose in evolution is a question of enduring interest. It is still unclear which developmental programmes are responsible for the emergence of the human brain. The inability to determine corresponding ages between humans and apes has hampered progress in detecting developmental programmes leading to the emergence of the human brain. I harness temporal variation in anatomical, behavioural and transcriptional variation to determine corresponding ages from fetal to postnatal development and ageing, between humans and chimpanzees. This multi-dimensional approach results in 137 corresponding time points across the lifespan, from embryonic day 44 to approximately 55 years of age, in humans and their equivalent ages in chimpanzees. I used these data to test whether developmental programmes, such as the timeline of prefrontal cortex (PFC) maturation, previously claimed to differ between humans and chimpanzees, do so once variation in developmental schedules is controlled for. I compared the maturation of frontal cortex projections from structural magnetic resonance (MR) scans and from temporal variation in the expression of genes used to track long-range projecting neurons (i.e. supragranular-enriched genes) in chimpanzees and humans. Contrary to what has been suggested, the timetable of PFC maturation is not unusually extended in humans. This dataset, which is the largest with which to determine corresponding ages across humans and chimpanzees, provides a rigorous approach to control for variation in developmental schedules and to identify developmental programmes responsible for unique features of the human brain.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.