Evidence map›Paper›PMID 33562731›Full record

ArticleInternational journal of molecular sciences2021

Genetic Bias, Diversity Indices, Physiochemical Properties and CDR3 Motifs Divide Auto-Reactive from Allo-Reactive T-Cell Repertoires.

Oscar L Haigh, Emma J Grant, Thi H O Nguyen, Katherine Kedzierska, Matt A Field, John J Miles

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
0.4field-weighted citation impact, top 39% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Article
  3. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 5 institutions in 2 countries.

Oscar L HaighCenter for Immunology of Viral, Auto-Immune, Hematological and Bacterial Diseases (IMVA-HB), Commissariat à l'Énergie Atomique et aux Énergies renouvelables, Université Paris-Saclay, INSERM U1184, Fontenay-aux-Roses, France.
Emma J GrantDepartment of Biochemistry and Genetics, La Trobe Institute for Molecular Science, La Trobe University, Melbourne, VIC 3086, Australia.
Thi H O NguyenDepartment of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0002-9294-7693
Katherine KedzierskaDepartment of Microbiology and Immunology, at the Peter Doherty Institute for Infection and Immunity, University of Melbourne, Parkville, VIC 3010, Australia.ORCID 0000-0001-6141-335X
Matt A FieldThe Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, Cairns, QLD 4811, Australia.ORCID 0000-0003-0788-6513
John J MilesThe Australian Institute of Tropical Health and Medicine (AITHM), James Cook University, Cairns, QLD 4811, Australia.ORCID 0000-0001-5506-6304
The University of Melbourne · AUAustralian National University · AUInserm · FRLa Trobe University · AUQIMR Berghofer Medical Research Institute · AU

Funding

Prostate Cancer Foundation Australia NCG 3913
6 · The paper itself

Abstract

The distinct properties of allo-reactive T-cell repertoires are not well understood. To investigate whether auto-reactive and allo-reactive T-cell repertoires encoded distinct properties, we used dextramer enumeration, enrichment, single-cell T-cell receptor (TCR) sequencing and multiparameter analysis. We found auto-reactive and allo-reactive T-cells differed in mean ex vivo frequency which was antigen dependent. Allo-reactive T-cells showed clear differences in TCR architecture, with enriched usage of specific T-cell receptor variable (

Indexed as

Antigens, NeoplasmGene Expression ProfilingHumansReceptors, Antigen, T-CellSequence Analysis, RNASingle-Cell AnalysisT-LymphocytesAntigens, NeoplasmReceptors, Antigen, T-CellT-cellT-cell alloreactivityT-cell receptorT-cell repertoire

Identifiers

PMID33562731
PMCPMC7915266
OpenAlexW3126459973

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.