Evidence map›Paper›PMID 33562706›Full record

ArticleCancers2021

Elucidating the Importance of DOT1L Recruitment in MLL-AF9 Leukemia and Hematopoiesis.

Sierrah M Grigsby, Ann Friedman, Jennifer Chase, Bridget Waas, James Ropa, Justin Serio, Chenxi Shen, Andrew G Muntean, Ivan Maillard, Zaneta Nikolovska-Coleska

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Cancers, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.8field-weighted citation impact, top 15% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 20 citations in OpenAlex.

  1. Review
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  13. Review
  14. The Role of DOT1L in Normal and Malignant Hematopoiesis.Frontiers in cell and developmental biology · 2022
    Review
  15. Review
  16. Gene Transcription as a Therapeutic Target in Leukemia.International journal of molecular sciences · 2021
    Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 1 institution in 1 country.

Sierrah M GrigsbyMolecular and Celular Graduate Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.ORCID 0000-0002-5410-8792
Ann FriedmanDepartment of Internal Medicine, Life Sciences Institute, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
Jennifer ChaseDepartment of Internal Medicine, Life Sciences Institute, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
Bridget WaasDepartment of Internal Medicine, Life Sciences Institute, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
James RopaMolecular and Celular Graduate Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
Justin SerioMolecular and Celular Graduate Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
Chenxi ShenMolecular and Celular Graduate Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
Andrew G MunteanMolecular and Celular Graduate Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
Ivan MaillardDepartment of Internal Medicine, Life Sciences Institute, University of Michigan Medical School, Ann Arbor, MI 48104, USA.
Zaneta Nikolovska-ColeskaMolecular and Celular Graduate Program, Department of Pathology, University of Michigan Medical School, Ann Arbor, MI 48104, USA.ORCID 0000-0001-6688-4206
University of Michigan · US

Funding

Proteogenomics of Cancer Training ProgramT32CA140044 · NCI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI RAO, ARVIND, SARTOR, MAUREEN AGNES · 2010 to 2024
$3.9M
Molecular functions of the shelterin component ACD/TPP1 in somatic stem cells and tissue homeostasisR01AG050509 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI KEEGAN, CATHERINE ELIZABETH, MAILLARD, IVAN · 2015 to 2019
$2.3M
The role of the PAFc subunit Cdc73 in normal hematopoiesis and transformationR01HL136420 · NHLBI · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI MUNTEAN, ANDREW GEORGE · 2018 to 2022
$1.9M
NCI NIH HHS T32 CA140044NHLBI NIH HHS R01 HL136420NIA NIH HHS R01 AG050509
6 · The paper itself

Abstract

PubMed holds no abstract for this paper.

Indexed as

Dot1lhematopoiesisMLL-rearrangement leukemiaprotein-protein interaction

Identifiers

PMID33562706
PMCPMC7914713
OpenAlexW3127998523

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.