Evidence map›Paper›PMID 33562703›Full record

ArticlePharmaceuticals (Basel, Switzerland)2021

Highly Efficient T2 Cobalt Ferrite Nanoparticles Vectorized for Internalization in Cancer Cells.

Eva Mazarío, Magdalena Cañete, Fernando Herranz, Jorge Sánchez-Marcos, Jesús M de la Fuente, Pilar Herrasti, Nieves Menéndez

Abstract read
In one paragraph

Article in Pharmaceuticals (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 3 papers.

0numbers the graph read from it
0cells of the map it votes in
3citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

3 citing papers in PubMed.

  1. Review
  2. PrPharmaceuticals (Basel, Switzerland) · 2023
    Article
  3. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors.

Eva MazaríoDepartamento de Química Física Aplicada, Facultad de Ciencias, Universidad Autónoma de Madrid, Francisco Tomás y Valiente 7, Cantoblanco, 28049 Madrid, Spain.ORCID 0000-0001-8235-0087
Magdalena CañeteDepartamento de Biología, Facultad de Ciencias, Universidad Autónoma de Madrid, C/Darwin 2, Cantoblanco, 28049 Madrid, Spain.
Fernando HerranzInstituto de Química Médica (IQM-CSIC) and CIBER de Enfermedades Respiratorias (CIBERES), Juan de la Cierva 3, 28006 Madrid, Spain.ORCID 0000-0002-3743-0050
Jorge Sánchez-MarcosDepartamento de Química Física Aplicada, Facultad de Ciencias, Universidad Autónoma de Madrid, Francisco Tomás y Valiente 7, Cantoblanco, 28049 Madrid, Spain.
Jesús M de la FuenteInstituto de Nanociencia y Materiales de Aragón, CSIC, Universidad de Zaragoza, C/Pedro Cerbuna 12, 50009 Zaragoza, Spain.ORCID 0000-0003-1081-8482
Pilar HerrastiDepartamento de Química Física Aplicada, Facultad de Ciencias, Universidad Autónoma de Madrid, Francisco Tomás y Valiente 7, Cantoblanco, 28049 Madrid, Spain.
Nieves MenéndezDepartamento de Química Física Aplicada, Facultad de Ciencias, Universidad Autónoma de Madrid, Francisco Tomás y Valiente 7, Cantoblanco, 28049 Madrid, Spain.ORCID 0000-0001-6357-1597

Funding

Spanish ministry of economy and competitiveness BIO2017-84246-C2-1-RSpanish ministry of economy and competitiveness PGC2018-095642-B-I00
6 · The paper itself

Abstract

Uniform cobalt ferrite nanoparticles have been synthesized using an electrochemical synthesis method in aqueous media. Their colloidal, magnetic, and relaxometric properties have been analyzed. The novelty of this synthesis relies on the use of iron and cobalt foils as precursors, which assures the reproducibility of the iron and cobalt ratio in the structure. A stable and biocompatible targeting conjugate nanoparticle-folic acid (NP-FA) was developed that was capable of targeting FA receptor positivity in HeLa (human cervical cancer) cancer cells. The biocompatibility of NP-FA was assessed in vitro in HeLa cells using the MTT assay, and morphological analysis of the cytoskeleton was performed. A high level of NP-FA binding to HeLa cells was confirmed through qualitative in vitro targeting studies. A value of 479 Fe+Co mM

Indexed as

cobalt ferritecontrast agentfolic acidinternalizationnanoparticlestargeting

Identifiers

PMID33562703
PMCPMC7914706

What OpenQuestion holds

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.