Evidence map›Paper›PMID 33562597›Full record

ArticlePharmaceutics2021

Boosting Antimicrobial Activity of Ciprofloxacin by Functionalization of Mesoporous Silica Nanoparticles.

Blanca de Juan Mora, Luís Filipe, Andreia Forte, Miguel M Santos, Celso Alves, Fernando Teodoro, Rui Pedrosa, Manuela Ribeiro Carrott, Luís C Branco, Sandra Gago

Open access · goldAbstract read
In one paragraph

Article in Pharmaceutics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
0.9field-weighted citation impact, top 32% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 12 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Article
  5. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

Blanca de Juan MoraLAQV-REQUIMTE, Departamento de Química da Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.
Luís FilipeLAQV-REQUIMTE, Departamento de Química da Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.
Andreia ForteLAQV-REQUIMTE, Departamento de Química da Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.
Miguel M SantosLAQV-REQUIMTE, Departamento de Química da Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.ORCID 0000-0001-8973-1595
Celso AlvesMARE-Marine and Environmental Sciences Centre, Politécnico de Leiria, Avenida Porto de Pesca, 2520-630 Peniche, Portugal.ORCID 0000-0003-1581-2127
Fernando TeodoroMARE-Marine and Environmental Sciences Centre, Politécnico de Leiria, Avenida Porto de Pesca, 2520-630 Peniche, Portugal.ORCID 0000-0001-5384-1469
Rui PedrosaMARE-Marine and Environmental Sciences Centre, Politécnico de Leiria, Avenida Porto de Pesca, 2520-630 Peniche, Portugal.
Manuela Ribeiro CarrottCentro de Química de Évora, LAQV-REQUIMTE, Instituto de Investigação e Formação Avançada, Departamento de Química, Escola de Ciências e Tecnologia, Colégio Luís António Verney, Universidade de Évora, 7000-671 Évora, Portugal.ORCID 0000-0003-4856-5150
Luís C BrancoLAQV-REQUIMTE, Departamento de Química da Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.
Sandra GagoLAQV-REQUIMTE, Departamento de Química da Faculdade de Ciências e Tecnologia, Universidade NOVA de Lisboa, Campus da Caparica, 2829-516 Caparica, Portugal.ORCID 0000-0003-0221-8508
Rede de Química e Tecnologia · PTInstituto Politécnico de Leiria · PTUniversity of Évora · PT

Funding

2003 Conference Pan-American Society Pigment Cell ReseaR13AR050006 · NIAMS · YALE UNIVERSITY · PI HALABAN, RUTH · 2003 to 2003
$8k
Fundação para a Ciência e a Tecnologia UIDB/50006/2020; UID/MAR/04292/2020;PTDC/QUI-QOR/32406/2017, PEst-C/LA0006/2013; MAR2020 (MAR-02.01.01-FEAMP-0042 - INOVA4AQUA
6 · The paper itself

Abstract

Mesoporous silica nanoparticles (MSNs) are very promising nanomaterials for treating bacterial infections when combined with pharmaceutical drugs. Herein, we report the preparation of two nanomaterials based on the immobilization of ciprofloxacin in mesoporous silica nanoparticles, either as the counter-ion of the choline derivative cation (MSN-[Ch][Cip]) or via anchoring on the surface of amino-group modified MSNs via an amide bond (MSN-Cip). Both nanomaterials were characterized by TEM, FTIR and solution

Indexed as

antimicrobial activityciprofloxacincytotoxicityionic liquidsmesoporous silica nanoparticles

Identifiers

PMID33562597
PMCPMC7914840
OpenAlexW3127438919

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.