Evidence map›Paper›PMID 33562475›Full record

ArticleMetabolites2021

The Increased Expression of Regulator of G-Protein Signaling 2 (RGS2) Inhibits Insulin-Induced Akt Phosphorylation and Is Associated with Uncontrolled Glycemia in Patients with Type 2 Diabetes.

J Gustavo Vazquez-Jimenez, M Stephanie Corpus-Navarro, J Miguel Rodriguez-Chavez, Hiram J Jaramillo-Ramirez, Judith Hernandez-Aranda, Octavio Galindo-Hernandez, J Rene Machado-Contreras, Marina Trejo-Trejo, Agustin Guerrero-Hernandez, J Alberto Olivares-Reyes

Open access · goldAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Metabolites, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 6 papers.

0numbers the graph read from it
0cells of the map it votes in
6citing papers in PubMed
0.6field-weighted citation impact, top 37% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

6 citing papers in PubMed, 13 citations in OpenAlex.

  1. Article
  2. Insulin resistance, CaFrontiers in physiology · 2025
    Review
  3. Multiple Roles of Palmitic Acid in Cardiovascular Diseases.Journal of inflammation research · 2025
    Review
  4. RGS2 and female common diseases: a guard of women's health.Journal of translational medicine · 2023
    Review
  5. Review
  6. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

10 authors at 3 institutions in 1 country.

J Gustavo Vazquez-JimenezDepartment of Biochemistry, Center for Research and Advanced Studies of the National Polytechnic Institute, CINVESTAV-IPN, Mexico City 07360, Mexico.
M Stephanie Corpus-NavarroLaboratory of Molecular Pathogenesis, School of Medicine, Campus Mexicali, Autonomous University of Baja California, Mexicali, Baja California 21000, Mexico.
J Miguel Rodriguez-ChavezLaboratory of Molecular Pathogenesis, School of Medicine, Campus Mexicali, Autonomous University of Baja California, Mexicali, Baja California 21000, Mexico.
Hiram J Jaramillo-RamirezDepartment of Internal Medicine, General Hospital of Mexicali, Mexicali, Baja California 21000, Mexico.
Judith Hernandez-ArandaDepartment of Biochemistry, Center for Research and Advanced Studies of the National Polytechnic Institute, CINVESTAV-IPN, Mexico City 07360, Mexico.
Octavio Galindo-HernandezLaboratory of Biochemistry, School of Medicine, Campus Mexicali, Autonomous University of Baja California, Mexicali, Baja California 21000, Mexico.ORCID 0000-0003-4960-7551
J Rene Machado-ContrerasLaboratory of Molecular Pathogenesis, School of Medicine, Campus Mexicali, Autonomous University of Baja California, Mexicali, Baja California 21000, Mexico.
Marina Trejo-TrejoSchool of Sports, Campus Mexicali, Autonomous University of Baja California, Mexicali, Baja California 21000, Mexico.
Agustin Guerrero-HernandezDepartment of Biochemistry, Center for Research and Advanced Studies of the National Polytechnic Institute, CINVESTAV-IPN, Mexico City 07360, Mexico.
J Alberto Olivares-ReyesDepartment of Biochemistry, Center for Research and Advanced Studies of the National Polytechnic Institute, CINVESTAV-IPN, Mexico City 07360, Mexico.ORCID 0000-0001-8389-9274
Universidad Autónoma de Baja California · MXCentro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional · MXMexicali Institute of Technology · MX

Funding

Centro de Investigación y de Estudios Avanzados del Instituto Politécnico Nacional Apoyo a la Investigación to J.A.O.-R. and A.G.-H.Consejo Nacional de Ciencia y Tecnología CONACYT/SEP 167673 to J.A.O.-R.Consejo Nacional de Ciencia y Tecnología FC2016/2803 to A.G-HFundación Miguel Alemán, A.C. Estimulo a la Investigacion Medica "Miguel Aleman Valdes" 2018 to J.A.O-RUniversidad Autónoma de Baja California Apoyo a la Investigación to J.G.V.-J
6 · The paper itself

Abstract

Experimental evidence in mice models has demonstrated that a high regulator of G-protein signaling 2 (RSG2) protein levels precede an insulin resistance state. In the same context, a diet rich in saturated fatty acids induces an increase in RGS2 protein expression, which has been associated with decreased basal metabolism in mice; however, the above has not yet been analyzed in humans. For this reason, in the present study, we examined the association between RGS2 expression and insulin resistance state. The incubation with palmitic acid (PA), which inhibits insulin-mediated Akt Ser

Indexed as

Akt proteinHbA1chuman endothelial cellsinsulin resistancepalmitic acidregulator of G-protein signaling 2type 2 diabetes mellitus

Identifiers

PMID33562475
PMCPMC7915073
OpenAlexW3128351151

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.