ArticleAntioxidants (Basel, Switzerland)2021
Grape Stem Extracts with Potential Anticancer and Antioxidant Properties.
Article in Antioxidants (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 29 papers.
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
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Who cites it
29 citing papers in PubMed, 54 citations in OpenAlex.
- Cardioprotective Potential of Grape-Derived Polyphenols in Cancer Therapy-Related Cardiotoxicity.International journal of molecular sciences · 2026Review
- Stem Cells in Cosmetic Applications: Advancements, Challenges, and Future Directions.Journal of cosmetic dermatology · 2026Review
- High Dietary Supplementation of Procyanidin-Rich Grape Seed Powders Enhances the Growth Performance and Muscle Crispness of Crisped Grass Carp.Animals : an open access journal from MDPI · 2026Article
- Oral plant-derived exosome-like nanovesicles: a new therapeutic perspective for intestinal diseases.Frontiers in pharmacology · 2026Review
- α-Mangostin, a safe and natural product as a candidate skin-whitening agent.Scientific reports · 2025Article
- The Bioaccessibility of Grape-Derived Phenolic Compounds: An Overview.Foods (Basel, Switzerland) · 2025Review
- Grape stems as sources of tryptophan and selenium: Functional properties and antioxidant potential.Food chemistry: X · 2025Article
- Effects of dietary supplementation with grape seed powders on growth performance and muscle nutrition of grass carp (Frontiers in physiology · 2025Article
- Mediterranean Food By-products as a Valuable Source of Bioactive Compounds with Health Properties.Current medicinal chemistry · 2025Review
- Exploring the Therapeutic Potential of Traditional Medicinal Foods in Cancer Treatment: Molecular Evidence and Bioactivities.Current topics in medicinal chemistry · 2025Review
- Squalene in Nanoparticles Improves Antiproliferative Effect on Human Colon Carcinoma Cells Through Apoptosis by Disturbances in Redox Balance.International journal of molecular sciences · 2024Article
- Biological Properties ofAntioxidants (Basel, Switzerland) · 2024Article
- Towards Sulphite-Free Winemaking: A New Horizon of Vinification and Maturation.Foods (Basel, Switzerland) · 2024Article
- Gut Microbiota Modulators Based on Polyphenols Extracted from Winery By-Products and Their Applications in the Nutraceutical Industry.Life (Basel, Switzerland) · 2024Review
- Revealing the Beauty Potential of Grape Stems: Harnessing Phenolic Compounds for Cosmetics.International journal of molecular sciences · 2023Review
- From Grape By-Products to Enriched Yogurt Containing Pomace Extract Loaded in Nanotechnological Nutriosomes Tailored for Promoting Gastro-Intestinal Wellness.Antioxidants (Basel, Switzerland) · 2023Article
- Antioxidant and antiproliferative potentials of phenolic-rich extracts from biotransformed grape pomace in colorectal Cancer.BMC complementary medicine and therapies · 2023Article
- Evaluation of grape stems and grape stem extracts for sulfur dioxide replacement during grape wine production.Current research in food science · 2023Article
- Mediterranean Food Industry By-Products as a Novel Source of Phytochemicals with a Promising Role in Cancer Prevention.Molecules (Basel, Switzerland) · 2022Review
- The Wine Industry By-Products: Applications for Food Industry and Health Benefits.Antioxidants (Basel, Switzerland) · 2022Review
Corrections and comments
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Authors and funding
7 authors at 2 institutions in 1 country.
Funding
Abstract
The application of plant extracts for therapeutic purposes has been used in traditional medicine because plants contain bioactive compounds with beneficial properties for health. Currently, the use of these compounds that are rich in polyphenols for the treatment and prevention of diseases such as cancer, diabetes, and cardiovascular diseases, many of them related to oxidative stress, is gaining certain relevance. Polyphenols have been shown to have antimutagenic, antioxidant, and anti-inflammatory properties. Therefore, the objective of the present work was to study the potential effect of grape stem extracts (GSE), rich in phenolic compounds, in the treatment of cancer, as well as their role in the prevention of this disease associated with its antioxidant power. For that purpose, three cancer lines (Caco-2, MCF-7, and MDA-MB-231) were used, and the results showed that grape stem extracts were capable of showing an antiproliferative effect in these cells through apoptosis cell death associated with a modification of the mitochondrial potential and reactive oxygen species (ROS) levels. Additionally, grape stem extracts showed an antioxidant effect on differentiated intestinal cells that could protect the intestine from diseases related to oxidative stress. Therefore, grape extracts contain bioactive principles with important biological properties and could be used as bio-functional food ingredients to prevent diseases or even to improve certain aspects of human health.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.