ReviewMolecules (Basel, Switzerland)2021
Selenium Biofortification: Roles, Mechanisms, Responses and Prospects.
Review in Molecules (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 65 papers.
What it found
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Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
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Who cites it
65 citing papers in PubMed, 231 citations in OpenAlex.
- XFM and HERFD-XAS studies of selenium in tissues and whole blood from mice supplemented with potentially therapeutic selenocompounds.Redox report : communications in free radical research · 2026Article
- Comparative bioaccumulation and biotransformation of selenate, selenite, and selenomethionine inBiochemistry and biophysics reports · 2026Article
- Integrated Physiological and Multi-Omics Analysis Reveals Selenium-Mediated Drought Tolerance inInternational journal of molecular sciences · 2026Article
- Effects of Selenomethionine Supplementation on Tomato Fruit Quality and Yield Under Deficit Irrigation.International journal of molecular sciences · 2026Article
- Systems-level transcriptomic and physiological adaptation of Bacillus licheniformis BLN313 to selenite stress.World journal of microbiology & biotechnology · 2026Article
- From Biofortification to HT-29 Growth Inhibition: Selenium-Enriched Sunflower Sprouts Modulate Apoptosis- and Cell Cycle-Related Markers.Foods (Basel, Switzerland) · 2026Article
- Selenium Speciation in Commonly Consumed Thai Seafood Under Different Cooking Methods.Foods (Basel, Switzerland) · 2026Article
- Deciphering the mechanism of selenium-induced resistance to TR4 in bananas via proteomic profiling.BMC plant biology · 2026Article
- Selenium Bioaccumulation inFoods (Basel, Switzerland) · 2026Article
- Selenium biofortification: integrating one health and sustainability.Journal of the science of food and agriculture · 2026Review
- Bioaccumulation of toxic and essential elements and enzymatic responses in native fish from the middle Tocantins River.Scientific reports · 2026Article
- Effects of L-selenomethionine supplementation on nutrient digestibility and metabolism, antioxidant capacity, hormone levels, and fecal microbiota diversity in pregnant Yili mares during mid- to late gestation.BMC veterinary research · 2026Article
- MsmiR171 targetsHorticulture research · 2026Article
- Characterization of Physicochemical Properties and Microbial Communities of Tibetan Plateau Selenium-Rich Soil.Microorganisms · 2026Article
- Identification of novel major quantitative trait loci associated with selenium and zinc accumulation inFrontiers in plant science · 2026Article
- Green manuring combined with rice straw return enhances secondary and micronutrients in rice grains in Southern China.Frontiers in plant science · 2026Article
- Redox Cascade in Chicken Skeletal Muscle: SELENOT Suppression in Selenium Deficiency Triggers Disulfidptosis via mtROS-NADPH Dysregulation.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Article
- Enhancing Nutritional and Functional Properties of Hydroponically Grown Underutilised Leafy Greens Through Selenium Biofortification.Plants (Basel, Switzerland) · 2025Article
- Empowering health with mushroom biofortification: nutritional and medicinal attributes.Journal of food science and technology · 2025Review
- Article
5 more citing papers are in PubMed but not listed here.
Corrections and comments
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Authors and funding
15 authors at 10 institutions in 6 countries.
Funding
Abstract
The trace element selenium (Se) is a crucial element for many living organisms, including soil microorganisms, plants and animals, including humans. Generally, in Nature Se is taken up in the living cells of microorganisms, plants, animals and humans in several inorganic forms such as selenate, selenite, elemental Se and selenide. These forms are converted to organic forms by biological process, mostly as the two selenoamino acids selenocysteine (SeCys) and selenomethionine (SeMet). The biological systems of plants, animals and humans can fix these amino acids into Se-containing proteins by a modest replacement of methionine with SeMet. While the form SeCys is usually present in the active site of enzymes, which is essential for catalytic activity. Within human cells, organic forms of Se are significant for the accurate functioning of the immune and reproductive systems, the thyroid and the brain, and to enzyme activity within cells. Humans ingest Se through plant and animal foods rich in the element. The concentration of Se in foodstuffs depends on the presence of available forms of Se in soils and its uptake and accumulation by plants and herbivorous animals. Therefore, improving the availability of Se to plants is, therefore, a potential pathway to overcoming human Se deficiencies. Among these prospective pathways, the Se-biofortification of plants has already been established as a pioneering approach for producing Se-enriched agricultural products. To achieve this desirable aim of Se-biofortification, molecular breeding and genetic engineering in combination with novel agronomic and edaphic management approaches should be combined. This current review summarizes the roles, responses, prospects and mechanisms of Se in human nutrition. It also elaborates how biofortification is a plausible approach to resolving Se-deficiency in humans and other animals.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.