Trial reportNutrients2021
Effects of Vitamin D Supplementation on Surrogate Markers of Fertility in PCOS Women: A Randomized Controlled Trial.
Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 25 papers, 5 of them syntheses that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
25 citing papers in PubMed, 5 syntheses or guidelines pooled it, 48 citations in OpenAlex.
- Influence of vitamin D supplementation on ovarian reserve as reflected by anti-Müllerian hormone levels: a meta-analysis of randomized controlled trials.Frontiers in endocrinology · 2026Pooled it
- A meta-analysis of the literature evaluating the impact of vitamin D on female fertility and ovarian reserve function.Revista da Escola de Enfermagem da U S P · 2026Pooled it
- The relationship between initial vitamin D levels andFrontiers in medicine · 2025Pooled it
- Comparison of dietary and physical activity behaviors in women with and without polycystic ovary syndrome: a systematic review and meta-analysis of 39 471 women.Human reproduction update · 2022Pooled it
- The effect of medication on serum anti-müllerian hormone (AMH) levels in women of reproductive age: a meta-analysis.BMC endocrine disorders · 2022Pooled it
- Effects of Vitamin D3 Treatment on Polycystic Ovary Symptoms: A Prospective Double-Blind Two-Phase Randomized Controlled Clinical Trial.Nutrients · 2025Trial
- Dingkun Pill-Mediated TGF-β1/Smad2 Pathway Effects on Granulosa Cell Proliferation and Apoptosis.Molecular biotechnology · 2026Article
- Unraveling the Complexity of Polycystic Ovary Syndrome: Biomarkers for Diagnosis, Prognosis, and Treatment.Current pharmaceutical design · 2026Review
- Redox-endocrine triad in PCOS: can vitamin D, myo-inositol, and melatonin synergize as bioactive cocktails?Frontiers in endocrinology · 2026Review
- Vitamin D in Endocrine Disorders: A Broad Overview of Evidence in Musculoskeletal, Thyroid, Parathyroid, and Reproductive Disorders.Pharmaceuticals (Basel, Switzerland) · 2025Review
- Vitamin D in Reproductive Health Disorders: A Narrative Review Focusing on Infertility, Endometriosis, and Polycystic Ovarian Syndrome.International journal of molecular sciences · 2025Review
- Supplement strategies for infertility in overweight women: Evidence and legal insights.Open medicine (Warsaw, Poland) · 2025Review
- Natural compounds in the management of polycystic ovary syndrome: a comprehensive review of hormonal regulation and therapeutic potential.Frontiers in nutrition · 2025Review
- Oviduct Glycoprotein 1 (OVGP1) Diagnoses Polycystic Ovary Syndrome (PCOS) Based on Machine Learning Algorithms.ACS omega · 2024Article
- The latest reports and treatment methods on polycystic ovary syndrome.Annals of medicine · 2024Review
- Obesity is associated with SHBG levels rather than blood lipid profiles in PCOS patients with insulin resistance.BMC endocrine disorders · 2024Article
- Mental Health Across the Menstrual Cycle in Polycystic Ovary Syndrome: Insights and Implications.Current psychiatry reports · 2024Review
- Does vitamin D supplementation impact serotonin levels? A systematic review and meta-analysis.Health science reports · 2024Article
- Do Popular Diets Impact Fertility?Nutrients · 2024Review
- Autophagy Proteins and clinical data reveal the prognosis of polycystic ovary syndrome.BMC pregnancy and childbirth · 2024Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Vitamin D (VD) might play an important role in polycystic ovary syndrome (PCOS) and female fertility. However, evidence from randomized controlled trials (RCT) is sparse. We examined VD effects on anti-Müllerian hormone (AMH) and other endocrine markers in PCOS and non-PCOS women. This is a post hoc analysis of a single-center, double-blind RCT conducted between December 2011 and October 2017 at the endocrine outpatient clinic at the Medical University of Graz, Austria. We included 180 PCOS women and 150 non-PCOS women with serum 25-hydroxyvitamin D (25(OH)D) concentrations <75 nmol/L in the trial. We randomized subjects to receive 20,000 IU of VD3/week (119 PCOS, 99 non-PCOS women) or placebo (61 PCOS, 51 non-PCOS women) for 24 weeks. Outcome measures were AMH, follicle-stimulating hormone (FSH), luteinizing hormone (LH), estradiol, dehydroepiandrosterone sulfate, and androstenedione. In PCOS women, we observed a significant treatment effect on FSH (mean treatment effect 0.94, 95% confidence interval [CI] 0.087 to 1.799,
Indexed as
Identifiers
What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.