Evidence map›Paper›PMID 33562188›Full record

ArticleDiagnostics (Basel, Switzerland)2021

Medulloblastoma Associated with Down Syndrome: From a Rare Event Leading to a Pathogenic Hypothesis.

Alessandra Boni, Marco Ranalli, Giada Del Baldo, Roberto Carta, Mariachiara Lodi, Emanuele Agolini, Martina Rinelli, Diletta Valentini, Sabrina Rossi, Viola Alesi and 10 more

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Diagnostics (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.5field-weighted citation impact, top 35% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 6 citations in OpenAlex.

  1. Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

20 authors at 4 institutions in 2 countries.

Alessandra BoniDepartment of Pediatrics, Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy.ORCID 0000-0002-8723-7224
Marco RanalliDepartment of Pediatrics, Sapienza University, Viale Regina Elena 324, 00161 Rome, Italy.
Giada Del BaldoDepartment of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.
Roberto CartaDepartment of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.
Mariachiara LodiDepartment of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.
Emanuele AgoliniLaboratory of Medical Genetics, IRCCS Bambino Gesù Children's Hospital, Piazza Sant'Onofrio 4, 00146 Rome, Italy.ORCID 0000-0001-6543-6225
Martina RinelliLaboratory of Medical Genetics, IRCCS Bambino Gesù Children's Hospital, Piazza Sant'Onofrio 4, 00146 Rome, Italy.
Diletta ValentiniPediatric and Infectious Disease Unit, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.
Sabrina RossiDepartment of Laboratories, Pathology Unit, Bambino Gesù Children's Hospital, Piazza Sant'Onofrio 4, 00146 Rome, Italy.
Viola AlesiLaboratory of Medical Genetics, IRCCS Bambino Gesù Children's Hospital, Piazza Sant'Onofrio 4, 00146 Rome, Italy.ORCID 0000-0001-7514-5683
Antonella CacchioneDepartment of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.
Evelina MieleDepartment of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.ORCID 0000-0002-4747-1032
Iside AlessiDepartment of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.
Anna Maria CaroleoDepartment of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.ORCID 0000-0003-1249-7301
Giovanna Stefania ColafatiNeuroradiology Unit, Department of Imaging, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.
Maria Antonietta De IorisDepartment of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.ORCID 0000-0002-2113-4505
Luigi BoccutoSchool of Nursing, College of Behavioral, Social and Health Sciences, Clemson University, Clemson, SC 29634, USA.
Mario BalducciDepartment of Imaging, Radiation Oncology and Haematology, Policlinico A. Gemelli Fundation, IRCCS, Catholic University of Sacred Heart, Largo A. Gemelli 1, 00168 Rome, Italy.
Andrea CaraiNeurosurgery Unit, Department of Neurological and Psychiatric Sciences, Bambino Gesù Children's Hospital, IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.ORCID 0000-0002-5203-7855
Angela MastronuzziDepartment of Onco-Hematology and Cell and Gene Therapy, Bambino Gesù Children's Hospital IRCCS, Piazza Sant'Onofrio 4, 00146 Rome, Italy.ORCID 0000-0002-4408-2373
Bambino Gesù Children's Hospital · ITSapienza University of Rome · ITAgostino Gemelli University Polyclinic · ITGreenwood Genetic Center · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Down syndrome (DS) is the most common chromosome abnormality with a unique cancer predisposition syndrome pattern: a higher risk to develop acute leukemia and a lower incidence of solid tumors. In particular, brain tumors are rarely reported in the DS population, and biological behavior and natural history are not well described and identified. We report a case of a 10-year-old child with DS who presented with a medulloblastoma (MB). Histological examination revealed a classic MB with focal anaplasia and the molecular profile showed the presence of a

Indexed as

brain tumorcancer predisposition syndromeDown syndromemedulloblastoma

Identifiers

PMID33562188
PMCPMC7915142
OpenAlexW3127528710

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.