Evidence map›Paper›PMID 33562071›Full record

ArticleCurrent oncology (Toronto, Ont.)2021

Novel Mutations in a Lethal Case of Lymphomatous Adult T Cell Lymphoma with Cryptic Myocardial Involvement.

Taraneh Hashemi Zonouz, Rami Abdulbaki, Bidhan C Bandyopadhyay, Victor E Nava

Open access · goldAbstract readCase Reports
PubMed Full text at PMC Publisher
In one paragraph

Article in Current oncology (Toronto, Ont.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.3field-weighted citation impact, top 47% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 5 citations in OpenAlex.

  1. Article
  2. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 1 institution in 1 country.

Taraneh Hashemi ZonouzPathology and Laboratory Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.
Rami AbdulbakiPathology and Laboratory Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.
Bidhan C BandyopadhyayCalcium Signaling Laboratory, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.ORCID 0000-0003-2364-8945
Victor E NavaPathology and Laboratory Service, Veterans Affairs Medical Center, 50 Irving Street, NW, Washington, DC 20422, USA.
George Washington University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The autopsy of a 65-year-old diabetic African American male revealed significant left myocardial involvement by adult T-cell leukemia/lymphoma (ATLL) despite normal pre-mortem fluorodeoxyglucose (FDG) uptake by positron emission tomography/computed tomography (PET/CT). Due to pre-existing diabetic cardiomyopathy with reduced ejection fraction (EF) and compatible imaging studies, cardiac lymphomatous involvement was not suspected. While peripheral blood was negative for leukemia, next-generation sequencing of a lymph node revealed at least eight novel mutations (AXIN1, R712Q, BARD1 R749K, CTNNB1 I315V, CUX1 P102T, DNMT3A S199R, FGFR2 S431L, LRP1B Y2560C and STAG2 I771M). These findings underscore a diagnostic pitfall in a rare lymphomatous variant of ATLL infiltrating myocardium and contribute to its molecular characterization.

Indexed as

Leukemia-Lymphoma, Adult T-CellLymphomaLymphoma, T-CellAdultAgedHumansMaleMutationMyocardiumPositron Emission Tomography Computed Tomographyadult T-cell leukemia/lymphomadiabetic cardiomyopathynext-generation sequencingpoint mutationsTCR/NF-kB

Identifiers

PMID33562071
PMCPMC7985755
OpenAlexW3129103284

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.