Evidence map›Paper›PMID 33562031›Full record

ReviewLife (Basel, Switzerland)2021

Oligodendroglial Heterogeneity in Neuropsychiatric Disease.

Sunniva M K Bøstrand, Anna Williams

Abstract readReview
In one paragraph

Review in Life (Basel, Switzerland), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
  4. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

2 authors.

Sunniva M K BøstrandCentre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh BioQuarter, 5, Little France Drive, Edinburgh EH16 4UU, UK.ORCID 0000-0003-1689-8583
Anna WilliamsCentre for Regenerative Medicine, Institute for Regeneration and Repair, The University of Edinburgh, Edinburgh BioQuarter, 5, Little France Drive, Edinburgh EH16 4UU, UK.ORCID 0000-0002-6329-382X

Funding

Chief Scientist Office CGA/18/20Medical Research Council Human Cell AtlasMedical Research Council MR/P016022/1Medical Research Council MR/S035915/1Medical Research Council MR/T015594/1Multiple Sclerosis Society Edinburgh Centre grantUK Dementia Research Institute DRIWellcome Trust Translational Neuroscience PhD programme
6 · The paper itself

Abstract

Oligodendroglia interact with neurons to support their health and maintain the normal functioning of the central nervous system (CNS). Human oligodendroglia are a highly heterogeneous population characterised by distinct developmental origins and regional differences, as well as variation in cellular states, as evidenced by recent analysis at single-nuclei resolution. Increasingly, there is evidence to suggest that the highly heterogeneous nature of oligodendroglia might underpin their role in a range of CNS disorders, including those with neuropsychiatric symptoms. Understanding the role of oligodendroglial heterogeneity in this group of disorders might pave the way for novel approaches to identify biomarkers and develop treatments.

Indexed as

heterogeneityHuntington’s diseaseneuropsychiatric diseaseoligodendrocyte

Identifiers

PMID33562031
PMCPMC7914430

What OpenQuestion holds

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Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.