Evidence map›Paper›PMID 33561990›Full record

SynthesisNutrients2021

Herbal Remedies and Their Possible Effect on the GABAergic System and Sleep.

Oliviero Bruni, Luigi Ferini-Strambi, Elena Giacomoni, Paolo Pellegrino

Open access · goldAbstract readSystematic Review
PubMed Full text at PMC Publisher
In one paragraph

Synthesis in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 47 papers, 3 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
47citing papers in PubMed, 3 pooled it
17.4field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

47 citing papers in PubMed, 3 syntheses or guidelines pooled it, 100 citations in OpenAlex.

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  11. Synergistic Effect ofPharmaceuticals (Basel, Switzerland) · 2026
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

4 authors at 3 institutions in 1 country.

Oliviero BruniDepartment of Developmental and Social Psychology, Sapienza University, 00185 Rome, Italy.ORCID 0000-0003-2207-1398
Luigi Ferini-StrambiDepartment of Neurology, Ospedale San Raffaele Turro, 20127 Milan, Italy.
Elena GiacomoniDepartment of Medical Affairs, Sanofi Consumer HealthCare, 20158 Milan, Italy.
Paolo PellegrinoDepartment of Medical Affairs, Sanofi Consumer HealthCare, 20158 Milan, Italy.
Sanofi (Italy) · ITSapienza University of Rome · ITVita-Salute San Raffaele University · IT

Funding

Sanofi N/A
6 · The paper itself

Abstract

Sleep is an essential component of physical and emotional well-being, and lack, or disruption, of sleep due to insomnia is a highly prevalent problem. The interest in complementary and alternative medicines for treating or preventing insomnia has increased recently. Centuries-old herbal treatments, popular for their safety and effectiveness, include valerian, passionflower, lemon balm, lavender, and Californian poppy. These herbal medicines have been shown to reduce sleep latency and increase subjective and objective measures of sleep quality. Research into their molecular components revealed that their sedative and sleep-promoting properties rely on interactions with various neurotransmitter systems in the brain. Gamma-aminobutyric acid (GABA) is an inhibitory neurotransmitter that plays a major role in controlling different vigilance states. GABA receptors are the targets of many pharmacological treatments for insomnia, such as benzodiazepines. Here, we perform a systematic analysis of studies assessing the mechanisms of action of various herbal medicines on different subtypes of GABA receptors in the context of sleep control. Currently available evidence suggests that herbal extracts may exert some of their hypnotic and anxiolytic activity through interacting with GABA receptors and modulating GABAergic signaling in the brain, but their mechanism of action in the treatment of insomnia is not completely understood.

Indexed as

BrainHumansPhytotherapyReceptors, GABASleepSleep Initiation and Maintenance DisordersSleep Wake DisordersReceptors, GABAGABA receptorsgamma-aminobutyric acidherbal medicineinsomniasleep

Identifiers

PMID33561990
PMCPMC7914492
OpenAlexW3126807205

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.