Trial reportNutrients2021
The Impact of Diet on Urinary Risk Factors for Cystine Stone Formation.
Trial report in Nutrients, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers, 1 of them a synthesis that pooled it.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
20 citing papers in PubMed, 1 synthesis or guideline pooled it, 29 citations in OpenAlex.
- Pharmacological interventions for the management of cystinuria: a systematic review.Journal of nephrology · 2024Pooled it
- Cystinuria Diagnosed at Age 67 Following a 49-Year Diagnostic Delay: A Reminder of Indolent Cystinuria in Adult Urolithiasis-A Case Report.Case reports in urology · 2026Article
- Comparison of vacuum-assisted flexible ureteroscopy and percutaneous nephrolithotomy for 2-3 cm upper tract stones: a real-world cohort study.Frontiers in surgery · 2026Article
- Personalised prevention and management of kidney stones: a narrative review on the importance of integrating environmental, social and genetic factors.Public health reviews · 2026Review
- Dietary salt and protein intake and urinary cystine excretion in patients with cystinuria.Clinical kidney journal · 2025Article
- Modulators of urinary pH in the context of urinary stone disease: a literature review.Translational andrology and urology · 2025Review
- Dietary Influence on Urolithiasis Risk Mediated by Plasma Metabolites: A Mendelian Randomization and Experimental Study Linking Genes, Metabolites, and Clinical Outcomes.Food science & nutrition · 2025Article
- Sulfide is a keystone metabolite for gut homeostasis and immunity.bioRxiv : the preprint server for biology · 2025Article
- The relationship between dietary live microbe intake and overactive bladder among American adults: a cross-sectional study from NHANES 2007-2018.Journal of health, population, and nutrition · 2024Article
- Medical management of urolithiasis: Great efforts and limited progress.Asian journal of urology · 2024Review
- [Prevention of recurrence of urolithiasis].Urologie (Heidelberg, Germany) · 2024Article
- Dietary cystine restriction increases the proliferative capacity of the small intestine of mice.PloS one · 2024Article
- Comprehensive prediction of urolithiasis based on clinical factors, blood chemistry and urinalysis: UROLITHIASIS score.Scientific reports · 2023Article
- Effect of pH, Norepinephrine and Glucose on Metabolic and Biofilm Activity of Uropathogenic Microorganisms.Microorganisms · 2023Article
- Characterizing Meat- and Milk/Dairy-like Vegetarian Foods and Their Counterparts Based on Nutrient Profiling and Food Labels.Foods (Basel, Switzerland) · 2023Article
- Article
- [Urolithiasis-Therapy and recurrence prevention taking into account gender-specific aspects].Urologie (Heidelberg, Germany) · 2022Review
- Enhancing KRSC advances · 2022Article
- Cystinuria: An Overview of Diagnosis and Medical Management.Turkish archives of pediatrics · 2022Article
- Article
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
4 authors at 1 institution in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Despite the importance of dietary management of cystinuria, data on the contribution of diet to urinary risk factors for cystine stone formation are limited. Studies on the physiological effects of diet on urinary cystine and cysteine excretion are lacking. Accordingly, 10 healthy men received three standardized diets for a period of five days each and collected daily 24 h urine. The Western-type diet (WD; 95 g/day protein) corresponded to usual dietary habits, whereas the mixed diet (MD; 65 g/day protein) and lacto-ovo-vegetarian diet (VD; 65 g/day protein) were calculated according to dietary reference intakes. With intake of the VD, urinary cystine and cysteine excretion decreased by 22 and 15%, respectively, compared to the WD, although the differences were not statistically significant. Urine pH was significantly highest on the VD. Regression analysis showed that urinary phosphate was significantly associated with cystine excretion, while urinary sulfate was a predictor of cysteine excretion. Neither urinary cystine nor cysteine excretion was affected by dietary sodium intake. A lacto-ovo-vegetarian diet is particularly suitable for the dietary treatment of cystinuria, since the additional alkali load may reduce the amount of required alkalizing agents.
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