ReviewInternational journal of molecular sciences2021
The Effect of Lead Exposure on Autism Development.
Review in International journal of molecular sciences, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 19 papers, 1 of them a synthesis that pooled it.
What it found
Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.
The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
The trial behind it
Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.
Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.
Who cites it
19 citing papers in PubMed, 1 synthesis or guideline pooled it, 34 citations in OpenAlex.
- Investigating the role of food pollutants in autism spectrum disorder: a comprehensive analysis of heavy metals, pesticides, and mycotoxins.Naunyn-Schmiedeberg's archives of pharmacology · 2025Pooled it
- Molecular and cellular mechanisms of lead-induced neurotoxicity: comparative insights from rodent and zebrafish models.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Evaluation of Lead exposure's link to autism-like behavior and Shank 3 gene expression in C57BL/6J mice.The Journal of veterinary medical science · 2026Article
- Associations of prenatal metal exposures with autism-related outcomes in the ECHO cohort.Environmental epidemiology (Philadelphia, Pa.) · 2026Article
- Unravelling lead-induced toxicity in mammals: the role of oxidative stress and apoptosis and their modulation by emerging therapeutic strategies.Biometals : an international journal on the role of metal ions in biology, biochemistry, and medicine · 2026Review
- Co-exposure to lead and cadmium is associated with increased severity of social deficits in children with autism spectrum disorders.Frontiers in nutrition · 2026Article
- Evaluation of Heavy Metals and Essential Minerals in the Hair of Children with Autism Spectrum Disorder and Their Association with Symptom Severity.Biological trace element research · 2025Article
- Whole blood lead concentrations in children undergoing autism assessment in a community paediatric clinic: a retrospective cross-sectional study.BMJ paediatrics open · 2025Article
- Vinpocetine, a Phosphodiesterase Type 1 Inhibitor, Mitigates Locomotor Hyperactivity in Female Mice Exposed to Lead During Development.Brain sciences · 2025Article
- EnvironMental Health: A Framework for an Emerging Field at the Intersection of the Environment and Mental Health Crises.GeoHealth · 2025Review
- Effects of prenatal lead, mercury, cadmium, and arsenic exposure on children's neurodevelopment in an artisanal small-scale gold mining area in Northwestern Tanzania using a multi-chemical exposure model.PLOS global public health · 2025Article
- Modulation of gut microbiota with probiotics as a strategy to counteract endogenous and exogenous neurotoxicity.Advances in neurotoxicology · 2024Article
- Lead contamination in human milk affects infants' language trajectory: results from a prospective cohort study.Frontiers in public health · 2024Article
- Interaction of Heavy Metal Lead with Gut Microbiota: Implications for Autism Spectrum Disorder.Biomolecules · 2023Review
- Bloodlettings in Hemochromatosis Result in Increased Blood Lead (Pb) Concentrations.Biological trace element research · 2023Article
- Topological network properties of resting-state functional connectivity patterns are associated with metal mixture exposure in adolescents.Frontiers in neuroscience · 2023Article
- Elemental composition of the hair and milk of black-spotted cows and its relationship with intestinal microbiome reorganization.Veterinary world · 2022Article
- Maternal lead exposure induces sex-dependent cerebellar glial alterations and repetitive behaviors.Frontiers in cellular neuroscience · 2022Article
- Autism Spectrum Disorder: Nature vs. Nurture.Missouri medicineArticle
Corrections and comments
PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.
Authors and funding
2 authors at 1 institution in 1 country.
Funding
Abstract
Autism Spectrum Disorder (ASD) remains one of the most detrimental neurodevelopmental conditions in society today. Common symptoms include diminished social and communication ability. Investigations on autism etiology remain largely ambiguous. Previous studies have highlighted exposure to lead (Pb) may play a role in ASD. In addition, lead has been shown to be one of the most prevalent metal exposures associated with neurological deficits. A semi-systematic review was conducted using public databases in order to evaluate the extent of lead's role in the etiology of autism. This review examines the relationship between autistic comorbid symptoms-such as deterioration in intelligence scores, memory, language ability, and social interaction-and lead exposure. Specifically, the mechanisms of action of lead exposure, including changes within the cholinergic, dopaminergic, glutamatergic, gamma aminobutyric acid (GABA)ergic systems, are discussed. The goal of this review is to help illustrate the connections between lead's mechanistic interference and the possible furthering of the comorbidities of ASD. Considerations of the current data and trends suggest a potential strong role for lead in ASD.
Indexed as
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What OpenQuestion holds
Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.