Evidence map›Paper›PMID 33561938›Full record

ReviewJournal of clinical medicine2021

Translational Relevance of Mouse Models of Atopic Dermatitis.

Justin Choi, Nishadh Sutaria, Youkyung Sophie Roh, Zachary Bordeaux, Martin P Alphonse, Shawn G Kwatra, Madan M Kwatra

Open access · goldAbstract readReview
In one paragraph

Review in Journal of clinical medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 13 papers.

0numbers the graph read from it
0cells of the map it votes in
13citing papers in PubMed
2.3field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

13 citing papers in PubMed, 15 citations in OpenAlex.

  1. Review
  2. Article
  3. Article
  4. Review
  5. Review
  6. Article
  7. Article
  8. Article
  9. Article
  10. International journal of molecular sciences · 2023
    Article
  11. Article
  12. Lymph-derived chemokines direct early neutrophil infiltration in the lymph nodes uponProceedings of the National Academy of Sciences of the United States of America · 2022
    Article
  13. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 2 institutions in 1 country.

Justin ChoiDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Nishadh SutariaDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Youkyung Sophie RohDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Zachary BordeauxDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.
Martin P AlphonseDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0003-3447-1284
Shawn G KwatraDepartment of Dermatology, Johns Hopkins University School of Medicine, Baltimore, MD 21231, USA.ORCID 0000-0003-3736-1515
Madan M KwatraDepartment of Anesthesiology, Duke University School of Medicine, Durham, NC 27710, USA.
Johns Hopkins University · USDuke University · US

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

The complexity of atopic dermatitis (AD) continues to present a challenge in the appropriate selection of a mouse model because no single murine model completely recapitulates all aspects of human AD. This has been further complicated by recent evidence of the distinct AD endotypes that are dictated by unique patterns of inflammation involving Th1, Th2, Th17, and Th22 axes. A review of currently used mouse models demonstrates that while all AD mouse models consistently exhibit Th2 inflammation, only some demonstrate concomitant Th17 and/or Th22 induction. As the current understanding of the pathogenic contributions of these unique endotypes and their potential therapeutic roles expands, ongoing efforts to maximize a given mouse model's homology with human AD necessitates a close evaluation of its distinct immunological signature.

Indexed as

atopic dermatitisdermatologyeczemaimmunologymouse models

Identifiers

PMID33561938
PMCPMC7914954
OpenAlexW3128539146

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.