ArticleNeurobiology of aging2021
Aging faster: worry and rumination in late life are associated with greater brain age.
Article in Neurobiology of aging, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 40 papers, 1 of them a synthesis that pooled it.
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The trial behind it
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Who cites it
40 citing papers in PubMed, 1 synthesis or guideline pooled it, 64 citations in OpenAlex.
- Risk factors for cancer-related cognitive impairment among individuals with lung cancer: a systematic review and meta-analysis.Supportive care in cancer : official journal of the Multinational Association of Supportive Care in Cancer · 2024Pooled it
- Brief Video-Delivered Intervention to Reduce Anxiety and Improve Functioning in Older Veterans: Pilot Randomized Controlled Trial.JMIR aging · 2024Trial
- Predictive values of pre-treatment brain age models to rTMS effects in neurocognitive disorder with depression: Secondary analysis of a randomised sham-controlled clinical trial.Dialogues in clinical neuroscience · 2024Trial
- tDCS reduces depression and state anxiety symptoms in older adults from the augmenting cognitive training in older adults study (ACT).Brain stimulationTrial
- Epigenetic age acceleration is associated with brain connectivity changes and the risk of major depression after trauma.medRxiv : the preprint server for health sciences · 2026Article
- Genetically informed dissection of multimodal brain aging and ten major psychiatric disorders.Molecular psychiatry · 2026Article
- Accelerated Brain Aging in Young Women with Posttraumatic Stress Disorder.Experimental neurobiology · 2026Article
- Gone fishin'… for distinct patterns of belief-updating in late-life worry and rumination.Frontiers in psychiatry · 2026Article
- Older and wiser? The neural correlates of worry induction and reappraisal in older adults.Neuropsychopharmacology : official publication of the American College of Neuropsychopharmacology · 2025Article
- Advancing Research on Suicide and Mental Health in Autistic Adults Through a Research Domain Criteria (RDoC)-Inspired Framework.Autism in adulthood · 2025Article
- Distinct gut microbiota profiles and network properties in older Korean individuals with subjective cognitive decline, mild cognitive impairment, and Alzheimer's disease.Alzheimer's research & therapy · 2025Article
- Prevalence and Predictors of Chemotherapy-Related Cognitive Impairment in Elderly Lung Cancer Patients: A Cross-Sectional Study.Brain and behavior · 2025Article
- Subjective and Objective Cancer-Related Cognitive Impairments Among Systemic and Radiation Therapy-Naïve Female Cancer Patients.Cancer medicine · 2025Article
- Brain age mediates gut microbiome dysbiosis-related cognition in older adults.Alzheimer's research & therapy · 2025Article
- Brooding, reflection, and anger rumination in late life suicidal behavior.Journal of affective disorders · 2025Article
- Brain Age Is Not a Significant Predictor of Relapse Risk in Late-Life Depression.Biological psychiatry. Cognitive neuroscience and neuroimaging · 2025Article
- A preliminary investigation of worry, cortical amyloid burden, and stressor-evoked brain and cardiovascular reactivity in older adults.Journal of affective disorders · 2024Article
- Sex differences in the association between repetitive negative thinking and neurofilament light.Npj mental health research · 2024Article
- Greater Neighborhood Disadvantage Is Associated with Alterations in Fetal Functional Brain Network Structure.The Journal of pediatrics · 2024Observational
- Hippocampal subfield volume in older adults with and without mild cognitive impairment: Effects of worry and cognitive reappraisal.Neurobiology of aging · 2024Article
Corrections and comments
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Authors and funding
7 authors at 1 institution in 1 country.
Funding
Abstract
Older adults with anxiety have lower gray matter brain volume-a component of accelerated aging. We have previously validated a machine learning model to predict brain age, an estimate of an individual's age based on voxel-wise gray matter images. We investigated associations between brain age and anxiety, depression, stress, and emotion regulation. We recruited 78 participants (≥50 years) along a wide range of worry severity. We collected imaging data and computed voxel-wise gray matter images, which were input into an existing machine learning model to estimate brain age. We conducted a multivariable linear regression between brain age and age, sex, race, education, worry, anxiety, depression, rumination, neuroticism, stress, reappraisal, and suppression. We found that greater brain age was significantly associated with greater age, male sex, greater worry, greater rumination, and lower suppression. Male sex, worry, and rumination are associated with accelerated aging in late life and expressive suppression may have a protective effect. These results provide evidence for the transdiagnostic model of negative repetitive thoughts, which are associated with cognitive decline, amyloid, and tau.
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Registered trials
Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.