Evidence map›Paper›PMID 33561581›Full record

ReviewAgeing research reviews2021

Is personality associated with dementia risk? A meta-analytic investigation.

Damaris Aschwanden, Jason E Strickhouser, Martina Luchetti, Yannick Stephan, Angelina R Sutin, Antonio Terracciano

Open access · greenAbstract readReview
PubMed Full text at PMC Publisher
In one paragraph

Review in Ageing research reviews, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers, 13 of them syntheses that pooled it.

0numbers the graph read from it
0cells of the map it votes in
84citing papers in PubMed, 13 pooled it
13.3field-weighted citation impact, top 1% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

84 citing papers in PubMed, 13 syntheses or guidelines pooled it, 108 citations in OpenAlex.

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  6. Personality and Risk of Arthritis in Six Longitudinal Samples.The journals of gerontology. Series B, Psychological sciences and social sciences · 2024
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  13. Neuroticism and Risk of Parkinson's Disease: A Meta-Analysis.Movement disorders : official journal of the Movement Disorder Society · 2021
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24 more citing papers are in PubMed but not listed here.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

6 authors at 2 institutions in 2 countries.

Damaris AschwandenFlorida State University, Tallahassee, USA. Electronic address: damaris.aschwanden@med.fsu.edu.
Jason E StrickhouserFlorida State University, Tallahassee, USA.
Martina LuchettiFlorida State University, Tallahassee, USA.
Yannick StephanEuromov, University of Montpellier, France.
Angelina R SutinFlorida State University, Tallahassee, USA.
Antonio TerraccianoFlorida State University, Tallahassee, USA.
Florida State University · USUniversité de Montpellier · FR

Funding

Prenatal and Early Life Antecedents of Personality: An Intergenerational Lifespan ApproachR01AG053297 · NIA · FLORIDA STATE UNIVERSITY · PI Angelina R Sutin · 2017 to 2026
$4.3M
Personality and Dementia: Mechanisms and TrajectoriesR01AG068093 · NIA · FLORIDA STATE UNIVERSITY · PI TERRACCIANO, ANTONIO · 2020 to 2024
$3.0M
Uric acid and behavioral and psychological symptoms of dementiaR21AG057917 · NIA · FLORIDA STATE UNIVERSITY · PI TERRACCIANO, ANTONIO · 2018 to 2019
$422k
NIA NIH HHS R01 AG053297NIA NIH HHS R01 AG068093NIA NIH HHS R21 AG057917
6 · The paper itself

Abstract

This study provides a quantitative synthesis of the prospective associations between personality traits (neuroticism, extraversion, openness, agreeableness, conscientiousness) and the risk of incident Alzheimer's disease and related dementias. We conducted five separate meta-analyses with 8-12 samples (N = 30,036 to 33,054) that were identified through a systematic literature search following the MOOSE guidelines. Higher neuroticism (HR = 1.24, 95% CI [1.17, 1.31]) and lower conscientiousness (HR = 0.77, 95% CI [0.73, 0.81]) were associated with increased dementia risk, even after accounting for covariates such as depressive symptoms. Lower extraversion (HR = 0.92, 95% CI [0.86, 0.97]), openness (HR = 0.91, 95% CI [0.86, 0.96]), and agreeableness (HR = 0.90, 95% CI [0.83, 0.98]) were also associated with increased risk, but these associations were less robust and not significant in fully adjusted models. No evidence of publication bias was found. The strength of associations was unrelated to publication year (i.e., no evidence of winner's curse). Meta-regressions indicated consistent effects for neuroticism, openness, and conscientiousness across methods to assess dementia, dementia type, follow-up length, sample age, minority, country, and personality measures. The association of extraversion and agreeableness varied by country. Our findings indicate robust associations of neuroticism and conscientiousness with dementia risk.

Indexed as

Alzheimer DiseasePersonalityHumansProspective StudiesAlzheimer’s diseaseConscientiousnessDementiaMeta-AnalysisNeuroticismPersonality traits

Identifiers

PMID33561581
PMCPMC8005464
OpenAlexW3126627207

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.