Evidence map›Paper›PMID 33561489›Full record

ArticleFree radical biology & medicine2021

Transgenic expression of SOD1 specifically in neurons of Sod1 deficient mice prevents defects in muscle mitochondrial function and calcium handling.

Yu Su, Bumsoo Ahn, Peter C D Macpherson, Rojina Ranjit, Dennis R Claflin, Holly Van Remmen, Susan V Brooks

Open access · greenAbstract read
In one paragraph

Article in Free radical biology & medicine, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 16 papers.

0numbers the graph read from it
0cells of the map it votes in
16citing papers in PubMed
1.4field-weighted citation impact, top 19% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

16 citing papers in PubMed, 22 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Article
  5. Review
  6. Reactive oxygen species in the pathogenesis of sarcopenia.Free radical biology & medicine · 2025
    Review
  7. Article
  8. Article
  9. Review
  10. Article
  11. Review
  12. ROS-activated CXCR2Experimental & molecular medicine · 2022
    Article
  13. Article
  14. MICU3 regulates mitochondrial CaCell death & disease · 2021
    Article
  15. Article
  16. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 4 institutions in 2 countries.

Yu SuDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Orthopedics, Second Xiangya Hospital, Central South University, Changsha, PR China.
Bumsoo AhnAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Peter C D MacphersonDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA.
Rojina RanjitAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA.
Dennis R ClaflinDepartment of Surgery, Section of Plastic Surgery, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA.
Holly Van RemmenAging and Metabolism Research Program, Oklahoma Medical Research Foundation, Oklahoma City, OK, USA; Department of Physiology, Oklahoma University Health Science Center, Oklahoma City, OK, USA; VA Medical Center, Oklahoma City, OK, USA.
Susan V BrooksDepartment of Molecular and Integrative Physiology, University of Michigan, Ann Arbor, MI, USA; Department of Biomedical Engineering, University of Michigan, Ann Arbor, MI, USA. Electronic address: svbrooks@umich.edu.
University of Michigan · USOklahoma Medical Research Foundation · USCentral South University · CNUniversity of Oklahoma Medical Center · US

Funding

Targeted DNA Methylation and Mitochondrial Heteroplasmy CoreP30AG050911 · NIA · UNIVERSITY OF OKLAHOMA HLTH SCIENCES CTR · PI HOLLY VAN REMMEN · 2015 to 2026
$13.9M
PROJECT 3: Neuromuscular redox homeostasis in mice lacking SOD1 and aging wild type mice subcontract at University of LiverpoolP01AG051442 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI JACKSON, MALCOLM JOSEPH · 2016 to 2020
$8.9M
Defining the relative roles of pre- and post-synaptic events in the initiation and progression of sarcopeniaR01AG050676 · NIA · UNIVERSITY OF MICHIGAN AT ANN ARBOR · PI BROOKS, SUSAN V, VAN REMMEN, HOLLY · 2016 to 2020
$3.3M
BLR&D Research Career Scientist Award ApplicationIK6BX005234 · VA · OKLAHOMA CITY VA MEDICAL CENTER · PI VAN REMMEN, HOLLY · 2020 to 2024
–
BLRD VA IK6 BX005234BLRD VA IK6 BX005238NIA NIH HHS P01 AG051442NIA NIH HHS P30 AG050911NIA NIH HHS R01 AG050676
6 · The paper itself

Abstract

Aging is accompanied by loss of muscle mass and force, known as sarcopenia. Muscle atrophy, weakness, and neuromuscular junction (NMJ) degeneration reminiscent of normal muscle aging are observed early in adulthood for mice deficient in Cu, Zn-superoxide dismutase (SOD, Sod1

Indexed as

CalciumMuscle, SkeletalAnimalsMiceMice, TransgenicMitochondriaNeuronsSuperoxide DismutaseSuperoxide Dismutase-1CalciumSod1 protein, mouseSuperoxide DismutaseSuperoxide Dismutase-1AgingCuZnSODExcitation contraction couplingMitochondriaOxidative stressSarcopenia

Identifiers

PMID33561489
PMCPMC8026109
OpenAlexW3126926092

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.