ArticleNeuron2021
Cochlear neural degeneration disrupts hearing in background noise by increasing auditory cortex internal noise.
Article in Neuron, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 84 papers.
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Who cites it
84 citing papers in PubMed, 134 citations in OpenAlex.
- Noise-induced hearing loss delays auditory learning and reduces the influence of acoustic evidence on choice.bioRxiv : the preprint server for biology · 2026Article
- Neural and autonomic predictors of future listening errors.bioRxiv : the preprint server for biology · 2026Article
- Synaptic zinc plasticity shapes adaptive and maladaptive cortical plasticity following cochlear injury.Science advances · 2026Article
- Noise-invariant representations of sound emerge along the canonical cortical hierarchy.PLoS biology · 2026Article
- Parallel Age-Related Cochlear Neural Degeneration and Cortical Gain Adaptation in Normal-Hearing Humans.The Journal of neuroscience : the official journal of the Society for Neuroscience · 2026Article
- Altered folate metabolism disrupts auditory function from neonatal vocalizations to adult perceptual precision.Journal of neurodevelopmental disorders · 2026Article
- Cochlear histopathology in macaques after noise-induced temporary threshold shifts.Hearing research · 2026Article
- Perceptual and neural biomarkers of distraction from an external sound source are not associated with tinnitus severity.bioRxiv : the preprint server for biology · 2026Article
- Fluoxetine minimally affects hearing loss but induces gene expression changes in the cochlear nuclei after noise exposure.PloS one · 2026Article
- Age-related auditory nerve deficits propagate central gain throughout the auditory system: Associations with cortical microstructure and speech recognition.Neurobiology of aging · 2026Article
- Age-related decline in temporal sound processing: insights from envelope steepness map in the mouse auditory cortex.Frontiers in aging neuroscience · 2026Article
- Steady-State Auditory Evoked Potentials in Workers Exposed to Occupational Noise.La Medicina del lavoro · 2025Article
- Orthogonal spectral and temporal envelope representation during the onset phase in auditory cortex.iScience · 2025Article
- A deep learning framework for understanding cochlear implants.bioRxiv : the preprint server for biology · 2025Article
- Cell type-specific plasticity in synaptic, intrinsic, and sound response properties of deep-layer cortical neurons after noise trauma.Science advances · 2025Article
- Consequences and Mechanisms of Noise-Induced Cochlear Synaptopathy and Hidden Hearing Loss, With Focuses on Signal Perception in Noise and Temporal Processing.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2025Review
- Article
- Prognostic significance of the QuickSIN score for future hearing threshold deterioration.Scientific reports · 2025Article
- Associations between physiological indicators of cochlear deafferentation and listening effort in military Veterans with normal audiograms.Hearing research · 2025Article
- Analysis of clinical audiological characteristics in children with Williams syndrome in China.Orphanet journal of rare diseases · 2025Article
24 more citing papers are in PubMed but not listed here.
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Authors and funding
2 authors at 2 institutions in 1 country.
Funding
Abstract
Correlational evidence in humans suggests that selective difficulties hearing in noisy, social settings may reflect premature auditory nerve degeneration. Here, we induced primary cochlear neural degeneration (CND) in adult mice and found direct behavioral evidence for selective detection deficits in background noise. To identify central determinants for this perceptual disorder, we tracked daily changes in ensembles of layer 2/3 auditory cortex parvalbumin-expressing inhibitory neurons and excitatory pyramidal neurons with chronic two-photon calcium imaging. CND induced distinct forms of plasticity in cortical excitatory and inhibitory neurons that culminated in net hyperactivity, increased neural gain, and reduced adaptation to background noise. Ensemble activity measured while mice detected targets in noise could accurately decode whether individual behavioral trials were hits or misses. After CND, random surges of hypercorrelated cortical activity occurring just before target onset reliably predicted impending detection failures, revealing a source of internal cortical noise underlying perceptual difficulties in external noise.
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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.