ArticleSchizophrenia bulletin2021
Classification of Psychoses Based on Immunological Features: A Machine Learning Study in a Large Cohort of First-Episode and Chronic Patients.
Article in Schizophrenia bulletin, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers, 1 of them a synthesis that pooled it.
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Who cites it
10 citing papers in PubMed, 1 synthesis or guideline pooled it, 16 citations in OpenAlex.
- Immune System Abnormalities in Schizophrenia: An Integrative View and Translational Perspectives.Frontiers in psychiatry · 2022Pooled it
- Exploration of Early-Treatment-Associated Changes in Metabolic and Inflammatory Biomarkers in First-Episode Psychosis in Italian Patients.International journal of molecular sciences · 2026Article
- AI at the Bedside of Psychiatry: Comparative Meta-Analysis of Imaging vs. Non-Imaging Models for Bipolar vs. Unipolar Depression.Journal of clinical medicine · 2026Review
- MentalAId: an improved DenseNet model to assist scalable psychosis assessment.BMC psychiatry · 2025Article
- Comprehensive bioinformatics analysis identifies hub genes associated with immune cell infiltration in early-onset schizophrenia.BMC psychiatry · 2025Article
- Peripheral inflammation is associated with impairments of inhibitory behavioral control and visual sensorimotor function in psychotic disorders.Schizophrenia research · 2023Article
- A machine learning approach on whole blood immunomarkers to identify an inflammation-associated psychosis onset subgroup.Molecular psychiatry · 2023Article
- Deregulation of complement components C4A and CSMD1 peripheral expression in first-episode psychosis and links to cognitive ability.European archives of psychiatry and clinical neuroscience · 2022Article
- One size does not fit all: trans-diagnostic immune signatures for personalized treatment of psychoses.Revista brasileira de psiquiatria (Sao Paulo, Brazil : 1999)Article
- Inflammation Subtypes and Translating Inflammation-Related Genetic Findings in Schizophrenia and Related Psychoses: A Perspective on Pathways for Treatment Stratification and Novel Therapies.Harvard review of psychiatryReview
Corrections and comments
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Authors and funding
24 authors at 11 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
For several years, the role of immune system in the pathophysiology of psychosis has been well-recognized, showing differences from the onset to chronic phases. Our study aims to implement a biomarker-based classification model suitable for the clinical management of psychotic patients. A machine learning algorithm was used to classify a cohort of 362 subjects, including 160 first-episode psychosis patients (FEP), 70 patients affected by chronic psychiatric disorders (schizophrenia, bipolar disorder, and major depressive disorder) with psychosis (CRO) and 132 health controls (HC), based on mRNA transcript levels of 56 immune genes. Models distinguished between FEP, CRO, and HC and between the subgroup of drug-free FEP and HC with a mean accuracy of 80.8% and 90.4%, respectively. Interestingly, by using the feature importance method, we identified some immune gene transcripts that contribute most to the classification accuracy, possibly giving new insights on the immunopathogenesis of psychosis. Therefore, our results suggest that our classification model has a high translational potential, which may pave the way for a personalized management of psychosis.
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