ArticlePLoS genetics2021
Vestigial mediates the effect of insulin signaling pathway on wing-morph switching in planthoppers.
Article in PLoS genetics, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 17 papers.
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17 citing papers in PubMed, 41 citations in OpenAlex.
- PDK1-mediated PI3K/Akt signaling regulates metabolic and developmental programs in a cosmopolitan pest.Pest management science · 2026Article
- A glucose-AMPK-FoxO-vestigial signaling axis underlies host sugar-mediated wing dimorphism in Laodelphax striatellus.Pest management science · 2026Article
- Reduction of Buchnera with rifampicin impairs the density-dependent induction of winged morph in pea aphid.Insect science · 2026Article
- Comparative phylotranscriptomics of four sympatric tetrigids provides implications for convergent evolution and morphological discordance.BMC genomics · 2026Article
- Opposing insulin signals underlie the same developmental switch across hemipteran insects.Science advances · 2026Article
- Syntaxin-1A Silencing by RNAi Disrupts Growth and Reproduction in the Asian Citrus Psyllid,Insects · 2025Article
- The maternal vGluT2 and embryonic mGluR3 signaling relay system controls offspring wing dimorphism in pea aphid.iScience · 2025Article
- A plant virus manipulates the long-winged morph of insect vectors.Proceedings of the National Academy of Sciences of the United States of America · 2024Article
- The diverse roles of insulin signaling in insect behavior.Frontiers in insect science · 2024Review
- Article
- A novel geneeLife · 2023Article
- Mitochondria dysfunction impairs Tribolium castaneum wing development during metamorphosis.Communications biology · 2022Article
- The transcription factor Zfh1 acts as a wing-morph switch in planthoppers.Nature communications · 2022Article
- Photoperiod controls wing polyphenism in a water strider independently of insulin receptor signalling.Proceedings. Biological sciences · 2022Article
- ThemicroPublication biology · 2022Article
- Neofunctionalization of a second insulin receptor gene in the wing-dimorphic planthopper, Nilaparvata lugens.PLoS genetics · 2021Article
- Transcriptome Analysis of the Regulatory Mechanism of FoxO on Wing Dimorphism in the Brown Planthopper,Insects · 2021Article
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7 authors at 2 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Wing polymorphism is an evolutionary feature found in a wide variety of insects, which offers a model system for studying the evolutionary significance of dispersal. In the wing-dimorphic planthopper Nilaparvata lugens, the insulin/insulin-like growth factor signaling (IIS) pathway acts as a 'master signal' that directs the development of either long-winged (LW) or short-winged (SW) morphs via regulation of the activity of Forkhead transcription factor subgroup O (NlFoxO). However, downstream effectors of the IIS-FoxO signaling cascade that mediate alternative wing morphs are unclear. Here we found that vestigial (Nlvg), a key wing-patterning gene, is selectively and temporally regulated by the IIS-FoxO signaling cascade during the wing-morph decision stage (fifth-instar stage). RNA interference (RNAi)-mediated silencing of Nlfoxo increase Nlvg expression in the fifth-instar stage (the last nymphal stage), thereby inducing LW development. Conversely, silencing of Nlvg can antagonize the effects of IIS activity on LW development, redirecting wing commitment from LW to the morph with intermediate wing size. In vitro and in vivo binding assays indicated that NlFoxO protein may suppress Nlvg expression by directly binding to the first intron region of the Nlvg locus. Our findings provide a first glimpse of the link connecting the IIS pathway to the wing-patterning network on the developmental plasticity of wings in insects, and help us understanding how phenotypic diversity is generated by the modification of a common set of pattern elements.
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