ReviewInternational journal of molecular sciences2020
Hyperuricemia and Hypertension, Coronary Artery Disease, Kidney Disease: From Concept to Practice.
Review in International journal of molecular sciences, 2020. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 53 papers.
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Who cites it
53 citing papers in PubMed, 83 citations in OpenAlex.
- Article
- Urate-lowering therapy in cardiovascular pharmacotherapy: from Mendelian randomization data to cardio-renal-metabolic risk modulation.European heart journal. Cardiovascular pharmacotherapy · 2026Review
- Effect of Perfluorooctanesulfonic Acid on Fibrin Clot Properties and Thrombin Generation: Linking Environmental Pollution with Cardiovascular Diseases.Journal of cardiovascular development and disease · 2026Article
- Elevated uric acid levels link to a higher cardiometabolic risk profile in adolescents.Journal of endocrinological investigation · 2026Article
- Estimated small dense low-density lipoprotein cholesterol and hyperuricemia in diabetic patients.Frontiers in endocrinology · 2026Article
- Article
- The impact of uric acid on acute coronary syndrome prognosis in elderly patients.Annals of medicine · 2025Article
- Association between famine exposure during early life and the risk of hyperuricemia in adulthood: a systematic review and meta-analysis.BMC nutrition · 2025Article
- Risk factors and predictive model for mortality in acute myocardial infarction with ventricular septal rupture at high altitudes.World journal of cardiology · 2025Article
- Association between uric acid to high-density lipoprotein cholesterol ratio and diabetic kidney disease in US adults.Scientific reports · 2025Article
- J-shaped association of serum uric acid with all-cause and cardiovascular mortality in patients with diabetic kidney disease.Acta diabetologica · 2025Article
- Impact of preoperative hyperuricemia on the prognosis of patients with acute type A aortic dissection.International journal of cardiology. Heart & vasculature · 2025Article
- Construction of a prediction model for coronary heart disease in type 2 diabetes mellitus: a cross-sectional study.Scientific reports · 2025Article
- Effect of Dietary Magnesium on the Association Between Serum Uric Acid and Female Infertility.International journal of women's health · 2025Article
- Prognostic role of the serum uric acid-to-serum creatinine ratio in patients with st-elevation myocardial infarction and multivessel coronary artery disease.Cardiology journal · 2025Article
- Association between occupational heat exposure and early renal dysfunction among Chinese petrochemical workers: a combined machine learning and WQS modeling study.Frontiers in public health · 2025Article
- Triglycerides as a mediator in the hyperuricemia-diabetes link: insights from a hypertensive Chinese population.Frontiers in endocrinology · 2025Article
- The gut microbiome: a vital link to hyperuricemia, gout and acute flares?Frontiers in endocrinology · 2025Article
- Higher C-reactive protein to high-density lipoprotein cholesterol ratio is associated with hyperuricemia in diabetes and prediabetes: a cross-sectional study.Frontiers in endocrinology · 2025Article
- The association between the cardiometabolic index and hyperuricemia: 2011-2016 NHANES.Frontiers in endocrinology · 2025Article
Corrections and comments
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Authors and funding
10 authors at 7 institutions in 1 country.
Funding
No grant is acknowledged in the PubMed record.
Abstract
Since the publication of the Framingham Heart Study, which suggested that uric acid should no longer be associated with coronary heart disease after additional adjustment for cardiovascular disease risk factors, the number of publications challenging this statement has dramatically increased. The aim of this paper was to review and discuss the most recent studies addressing the possible relation between sustained elevated serum uric acid levels and the onset or worsening of cardiovascular and renal diseases. Original studies involving American teenagers clearly showed that serum uric acid levels were directly correlated with systolic and diastolic pressures, which has been confirmed in adult cohorts revealing a 2.21-fold increased risk of hypertension. Several studies involving patients with coronary artery disease support a role for serum uric acid level as a marker and/or predictor for future cardiovascular mortality and long-term adverse events in patients with coronary artery disease. Retrospective analyses have shown an inverse relationship between serum uric acid levels and renal function, and even a mild hyperuricemia has been shown to be associated with chronic kidney disease in patients with type 2 diabetes. Interventional studies, although of small size, showed that uric acid (UA)-lowering therapies induced a reduction of blood pressure in teenagers and a protective effect on renal function. Taken together, these studies support a role for high serum uric acid levels (>6 mg/dL or 60 mg/L) in hypertension-associated morbidities and should bring awareness to physicians with regards to patients with chronic hyperuricemia.
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