Influence of alphaxalone on motor somatosensory evoked potentials in a female rhesus macaque (

Henri Georges Michel Justin Bertrand, Joseph Adam Middleton, Stuart Nicolas Baker, Isabel Glover, Paul Andrew Flecknell

Open access · hybridAbstract read

In one paragraph

Article in Laboratory animals, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Not yet cited in PubMed.

0numbers the graph read from it

0cells of the map it votes in

0citing papers in PubMed

–field-weighted citation impact, top 99% of its field

1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

0 citing papers in PubMed, 0 citations in OpenAlex.

No citing paper in PubMed yet.

4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Henri Georges Michel Justin BertrandUniversity Biomedical Services, University of Cambridge, UK.ORCID https://orcid.org/0000-0002-1082-8384

Joseph Adam MiddletonFaculty of Life Science and Medicine, King's College London, UK.

Stuart Nicolas BakerInstitute of Neuroscience, Newcastle University, UK.

Isabel GloverInstitute of Neuroscience, Newcastle University, UK.

Paul Andrew FlecknellInstitute of Neuroscience, Newcastle University, UK.

Newcastle University · GBKing's College London · GBUniversity of Cambridge · GB

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

This communication reports the effect of alphaxalone on motor somatosensory evoked potential (SEPs) in a rhesus macaque. The animal was deeply anaesthetised with an infusion of ketamine, medetomidine, midazolam and alfentanil. The median nerve was stimulated, and SEPs were recorded from the motor cortex. The successive administration of three doses of alphaxalone (0.5, 1 and 2 mg/kg) induced an increase of the latency time and a decrease of the amplitude of the SEPs. However, the structure of the waveforms was conserved, and hence alphaxalone might represent a suitable general anaesthetic option in neuroscience research as well as veterinary or human medicine.

Indexed as

Motor CortexPregnanedionesAnimalsElectric StimulationEvoked Potentials, SomatosensoryFemaleHumansMacaca mulattaalphaxalonePregnanedionesAlphaxaloneneurosurgeryprimatesomatosensory evoked potential

Identifiers

PMID33560908

DOI10.1177/0023677221990706

PMCPMC8361466

OpenAlexW3123945826

What OpenQuestion holds

Textmetadata

LicenceCC BY

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Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.