Evidence map›Paper›PMID 33560875›Full record

Trial reportCephalalgia : an international journal of headache2021

Effect of comorbid migraine on propranolol efficacy for painful TMD in a randomized controlled trial.

Inna E Tchivileva, Richard Ohrbach, Roger B Fillingim, Pei Feng Lim, Massimiliano Di Giosia, Margarete Ribeiro-Dasilva, John H Campbell, Holly Hadgraft, Janet Willis, Samuel J Arbes and 1 more

Registry-linked trialOpen access · hybridAbstract readRandomized Controlled Trial
PubMed Full text at PMC Publisher
In one paragraph

Trial report in Cephalalgia : an international journal of headache, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. It is linked to trial NCT02437383 (Effect of COMT), which is not on this map. Cited by 7 papers, 1 of them a synthesis that pooled it.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed, 1 pooled it
2.0field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

NCT02437383 phase2completednot on this map

Effect of COMT (Catecholamine-O-methyltransferase) Genetic Polymorphisms on Response to Propranolol Therapy in Temporomandibular Disorder

TypeinterventionalSponsorUniversity of North Carolina, Chapel HillRan2015 to 2018Enrolled200ConditionsTemporomandibular DisordersArmsPropranolol ER, Placebo
3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 1 synthesis or guideline pooled it, 18 citations in OpenAlex.

  1. Pooled it
  2. Review
  3. Article
  4. Review
  5. Article
  6. Article
  7. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 4 institutions in 1 country.

Inna E TchivilevaCenter for Pain Research and Innovation, Adams School of Dentistry, 2331University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.ORCID 0000-0003-0968-0594
Richard OhrbachDepartment of Oral Diagnostic Sciences, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA.
Roger B FillingimDepartment of Community Dentistry and Behavioral Science, College of Dentistry, 3463University of Florida, Gainesville, FL, USA.
Pei Feng LimCenter for Pain Research and Innovation, Adams School of Dentistry, 2331University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Massimiliano Di GiosiaCenter for Pain Research and Innovation, Adams School of Dentistry, 2331University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
Margarete Ribeiro-DasilvaDepartment of Restorative Dental Science, Prosthodontics Division, College of Dentistry, 3463University of Florida, Gainesville, FL, USA.
John H CampbellDepartment of Oral and Maxillofacial Surgery, School of Dental Medicine, University at Buffalo, State University of New York, Buffalo, NY, USA.
Holly Hadgraft6015Rho Inc, Durham, NC, USA.
Janet Willis6015Rho Inc, Durham, NC, USA.
Samuel J Arbes6015Rho Inc, Durham, NC, USA.
Gary D SladeCenter for Pain Research and Innovation, Adams School of Dentistry, 2331University of North Carolina at Chapel Hill, Chapel Hill, NC, USA.
University of North Carolina at Chapel Hill · USRho (United States) · USUniversity at Buffalo, State University of New York · USUniversity of Florida · US

Funding

Effect of COMT genetic polymorphisms on response to propranolol therapy in TMDU01DE024169 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARBES, SAMUEL, FILLINGIM, ROGER B · 2014 to 2018
$4.7M
Effect of COMT genetic polymorphism on response to propranolol therapy in TMDR34DE022088 · NIDCR · UNIV OF NORTH CAROLINA CHAPEL HILL · PI ARBES, SAMUEL, SLADE, GARY DOUGLAS · 2012 to 2012
$239k
NIDCR NIH HHS R34 DE022088NIDCR NIH HHS U01 DE024169
6 · The paper itself

Abstract

introductionThe migraine-preventive drug propranolol is efficacious in reducing pain from temporomandibular disorder, suggesting potential modifying or mediating effects of comorbid migraine.

methodsIn this randomized controlled trial, myofascial temporomandibular disorder patients were treated with propranolol or placebo for 9 weeks. The primary endpoint was change in a facial pain index derived from daily symptom diaries. Linear and logistic regression models tested for a migraine × treatment-group interaction in reducing facial pain index. Counterfactual models explored changes in headache impact and heart rate as mediators of propranolol's efficacy.

resultsPropranolol's efficacy in reducing facial pain index was greater among the 104 migraineurs than the 95 non-migraineurs: For example, for the binary ≥ 30% reduction in facial pain index, odds ratios were 3.3 (95% confidence limits: 1.4, 8.1) versus 1.3 (0.5, 3.2), respectively, although the interaction was statistically non-significant (

conclusionsPropranolol was more efficacious in reducing temporomandibular disorder pain among migraineurs than non-migraineurs, with more of the effect mediated by reduced heart rate than by reduced headache impact. STUDY IDENTIFICATION AND REGISTRATION: SOPPRANO; NCT02437383; https://clinicaltrials.gov/ct2/show/NCT02437383.

Indexed as

AdolescentAdultAgedAutonomic Nervous SystemChronic PainDouble-Blind MethodFacial PainFemaleHumansMaleMiddle AgedMigraine DisordersPropranololSympathetic Nervous SystemTemporomandibular Joint DisordersTreatment OutcomePropranololAdrenergic beta-antagonistsautonomic nervous systemchronic painfacial painheadachesympathetic nervous system

Identifiers

PMID33560875
PMCPMC8166404
OpenAlexW3128851530

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC
Read underepoch 390

Registered trials

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.