Evidence map›Paper›PMID 33560848›Full record

ArticleJournal of proteome research2021

Simplified and Unified Access to Cancer Proteogenomic Data.

Caleb M Lindgren, David W Adams, Benjamin Kimball, Hannah Boekweg, Sadie Tayler, Samuel L Pugh, Samuel H Payne

Open access · hybridAbstract read
In one paragraph

Article in Journal of proteome research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 24 papers.

0numbers the graph read from it
0cells of the map it votes in
24citing papers in PubMed
2.2field-weighted citation impact, top 12% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

24 citing papers in PubMed, 37 citations in OpenAlex.

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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

7 authors at 1 institution in 1 country.

Caleb M LindgrenBiology Department, Brigham Young University, Provo, Utah 84602, United States.ORCID 0000-0001-6484-9757
David W AdamsBiology Department, Brigham Young University, Provo, Utah 84602, United States.
Benjamin KimballBiology Department, Brigham Young University, Provo, Utah 84602, United States.
Hannah BoekwegBiology Department, Brigham Young University, Provo, Utah 84602, United States.
Sadie TaylerBiology Department, Brigham Young University, Provo, Utah 84602, United States.
Samuel L PughBiology Department, Brigham Young University, Provo, Utah 84602, United States.
Samuel H PayneBiology Department, Brigham Young University, Provo, Utah 84602, United States.ORCID 0000-0002-8351-1994
Brigham Young University · US

Funding

Proteogenomic Data Analysis for Cancer Systems Biology and Clinical TranslationU24CA210972 · NCI · NEW YORK UNIVERSITY SCHOOL OF MEDICINE · PI DING, LI, FENYO, DAVID · 2016 to 2020
$3.3M
NCI NIH HHS U24 CA210972
6 · The paper itself

Abstract

Comprehensive cancer data sets recently generated by the Clinical Proteomic Tumor Analysis Consortium (CPTAC) offer great potential for advancing our understanding of how to combat cancer. These data sets include DNA, RNA, protein, and clinical characterization for tumor and normal samples from large cohorts of many different cancer types. The raw data are publicly available at various Cancer Research Data Commons. However, widespread reuse of these data sets is also facilitated by easy access to the processed quantitative data tables. We have created a data application programming interface (API) to distribute these processed tables, implemented as a Python package called cptac. We implement it such that users who prefer to work in R can easily use our package for data access and then transfer the data into R for analysis. Our package distributes the finalized processed CPTAC data sets in a consistent, up-to-date format. This consistency makes it easy to integrate the data with common graphing, statistical, and machine-learning packages for advanced analysis. Additionally, consistent formatting across all cancer types promotes the investigation of pan-cancer trends. The data API structure of directly streaming data within a programming environment enhances the reproducibility. Finally, with the accompanying tutorials, this package provides a novel resource for cancer research education. View the software documentation at https://paynelab.github.io/cptac/. View the GitHub repository at https://github.com/PayneLab/cptac.

Indexed as

NeoplasmsProteogenomicsHumansProteomicsReproducibility of ResultsSoftwarecancerCPTACdata accessdata disseminationgenomicsmass spectrometryproteogenomicsproteomicsPythonRreproducibility

Identifiers

PMID33560848
PMCPMC8022323
OpenAlexW3127165784

What OpenQuestion holds

Textmetadata
LicenceCC BY-NC-ND
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.