ArticleBrain and behavior2021
The role of interindividual licking received and dopamine genotype on later-life licking provisioning in female rat offspring.
Article in Brain and behavior, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.
What it found
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The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.
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Who cites it
5 citing papers in PubMed, 8 citations in OpenAlex.
- Mother-Young Bonding: Neurobiological Aspects and Maternal Biochemical Signaling in Altricial Domesticated Mammals.Animals : an open access journal from MDPI · 2023Review
- Hunting for Genes Underlying Emotionality in the Laboratory Rat: Maps, Tools and Traps.Current neuropharmacology · 2023Review
- Article
- Mother-young bond in non-human mammals: Neonatal communication pathways and neurobiological basis.Frontiers in psychology · 2022Review
- The role of interindividual licking received and dopamine genotype on later-life licking provisioning in female rat offspring.Brain and behavior · 2021Article
Corrections and comments
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Authors and funding
7 authors at 3 institutions in 2 countries.
Funding
No grant is acknowledged in the PubMed record.
Abstract
introductionRat mothers exhibit natural variations in care that propagate between generations of female offspring. However, there is limited information on genetic variation that could influence this propagation.
methodsWe assessed early-life maternal care received by individual female rat offspring, later-life maternal care provisioning, and dopaminergic activity in the maternal brain in relation to naturally occurring genetic polymorphisms linked to the dopaminergic system. We also conducted a systematic analysis of other genetic variants potentially related to maternal behavior in our Long-Evans rat population.
resultsWhile we did not find a direct relationship between early-life licking received and later-life licking provisioning, this relationship was indirectly affected by dopamine levels in the nucleus accumbens and dependent on variation in the dopamine receptor 2 gene (rs107017253). More specifically, female rat offspring with the A/G genotype showed a positive relationship between average licking received and dopamine levels in the nucleus accumbens of the maternal brain; there was no relationship with female rat offspring with the A/A genotype. The higher dopamine levels in the nucleus accumbens corresponded with higher maternal licking provisioning from postnatal days 2-9. We also discovered and validated several new variants that were predicted by our systematic analysis.
conclusionOur findings suggest that genetic variation influences the relationship between early-life maternal care received and the dopaminergic system of the maternal brain, which can indirectly influence later-life maternal care provisioning.
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