Evidence map›Paper›PMID 33560456›Full record

ReviewDer Pathologe2021

[COVID-19: effects on the lungs and heart].

Maximilian Ackermann, Christopher Werlein, Florian Länger, Mark P Kühnel, Danny D Jonigk

Open access · bronzeAbstract readReview
In one paragraph

Review in Der Pathologe, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 10 papers.

0numbers the graph read from it
0cells of the map it votes in
10citing papers in PubMed
1.0field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

10 citing papers in PubMed, 17 citations in OpenAlex.

  1. Article
  2. Pulmonary function assessment after COVID-19 in vaccinated healthcare workers.Journal of occupational medicine and toxicology (London, England) · 2023
    Article
  3. Review
  4. Review
  5. Time-Dependent Molecular Motifs of Pulmonary Fibrogenesis in COVID-19.International journal of molecular sciences · 2022
    Article
  6. Review
  7. Review
  8. Review
  9. Review
  10. Review
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

5 authors at 3 institutions in 1 country.

Maximilian AckermannInstitut für Pathologie und Molekularpathologie, Helios Universitätsklinikum Wuppertal, Universität Witten-Herdecke, Heusnerstr. 40, 42283, Wuppertal, Deutschland. maximilian.ackermann@helios-gesundheit.de.
Christopher WerleinInstitut für Pathologie, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Florian LängerInstitut für Pathologie, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Mark P KühnelInstitut für Pathologie, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland.
Danny D JonigkInstitut für Pathologie, Medizinische Hochschule Hannover (MHH), Carl-Neuberg-Str. 1, 30625, Hannover, Deutschland. Jonigk.Danny@MH-Hannover.de.
Medizinische Hochschule Hannover · DEGerman Center for Lung Research · DEHelios Universitätsklinikum Wuppertal · DE

Funding

Adult Tissue Morphogenesis: Functional Regulation of Intussusceptive AngiogenesisR01HL094567 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI MENTZER, STEVEN · 2009 to 2016
$3.2M
Formation of the Elastin Line Element in the Developing LungF32HL134229 · NHLBI · BRIGHAM AND WOMEN'S HOSPITAL · PI VALENZUELA, CRISTIAN DAVID · 2016 to 2016
$57k
NHLBI NIH HHS F32 HL134229NHLBI NIH HHS R01 HL094567
6 · The paper itself

Abstract

Viral respiratory diseases constitute the most common reasons for hospitalization with more than half of all acute illnesses worldwide. Progressive respiratory failure with pronounced diffuse alveolar damage has been identified as the primary cause of death in COVID-19. COVID-19 pneumonia shares common histopathological hallmarks with influenza (H1N1)-related ARDS, like diffuse alveolar damage (DAD) with edema, hemorrhage, and intra-alveolar fibrin deposition. The lungs with COVID-19 pneumonia revealed perivascular inflammation, an endothelial injury, microangiopathy, and an aberrant blood vessel neoformation by intussusceptive angiogenesis. While this pronounced angiocentric inflammation is likely be found - to varying degrees - in numerous other organs, e.g., the heart, COVID-19 is hypothesized to be not just a pulmonary, but rather a systemic "vascular disease."

Indexed as

COVID-19Influenza A Virus, H1N1 SubtypeHeartHumansLungSARS-CoV-2AngiogenesisHuman influenzaPneumoniaRespiratory distress syndromeSARS-CoV‑2

Identifiers

PMID33560456
PMCPMC7871953
OpenAlexW3126655087

What OpenQuestion holds

Textmetadata
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.