Evidence map›Paper›PMID 33560226›Full record

ArticleeLife2021

Intronic enhancer region governs transcript-specific

Jürgen Tuvikene, Eli-Eelika Esvald, Annika Rähni, Kaie Uustalu, Anna Zhuravskaya, Annela Avarlaid, Eugene V Makeyev, Tõnis Timmusk

Open access · goldAbstract read
In one paragraph

Article in eLife, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.3field-weighted citation impact, top 11% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 33 citations in OpenAlex.

  1. Article
  2. Article
  3. Article
  4. Mapping rat lncRNA Bdnf-as.Molecular biology reports · 2025
    Article
  5. Stimulus-Dependent Expression ofThe Journal of neuroscience : the official journal of the Society for Neuroscience · 2025
    Article
  6. Review
  7. Review
  8. Article
  9. Article
  10. Article
  11. Article
  12. Article
  13. Regulation of Satiety byBiomolecules · 2023
    Article
  14. Diverse Functions of MultipleBiomolecules · 2023
    Review
  15. Article
  16. Article
  17. Review
  18. Review
  19. Article
  20. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

8 authors at 2 institutions in 2 countries.

Jürgen TuvikeneDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.ORCID 0000-0002-9665-760X
Eli-Eelika Esvald *Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.ORCID 0000-0001-5730-8207
Annika Rähni *Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.ORCID 0000-0002-2826-4636
Kaie Uustalu *Department of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.
Anna ZhuravskayaCentre for Developmental Neurobiology, King's College London, London, United Kingdom.ORCID 0000-0001-9312-1212
Annela AvarlaidDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.ORCID 0000-0002-5941-8271
Eugene V MakeyevCentre for Developmental Neurobiology, King's College London, London, United Kingdom.ORCID 0000-0001-6034-6896
Tõnis TimmuskDepartment of Chemistry and Biotechnology, Tallinn University of Technology, Tallinn, Estonia.ORCID 0000-0002-1015-3348
Tallinn University of Technology · EEKing's College London · GB

Funding

Biotechnology and Biological Sciences Research Council BB/M001199/1Biotechnology and Biological Sciences Research Council BB/M007103/1Biotechnology and Biological Sciences Research Council BB/R001049/1
6 · The paper itself

Abstract

Brain-derived neurotrophic factor (BDNF) controls the survival, growth, and function of neurons both during the development and in the adult nervous system.

Indexed as

Gene Expression RegulationIntronsPromoter Regions, GeneticAnimalsBrain-Derived Neurotrophic FactorFemaleHumansMaleMiceNeuronsRatsRats, Sprague-DawleyBdnf protein, ratBrain-Derived Neurotrophic FactorBDNFchromosomesCRISPRE-boxenhancergene expressionhumanmouseneuronsneuroscienceratTCF4

Identifiers

PMID33560226
PMCPMC7891933
OpenAlexW3128946479

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.