Evidence map›Paper›PMID 33559882›Full record

ArticleThe Journal of physiology2021

MET currents and otoacoustic emissions from mice with a detached tectorial membrane indicate the extracellular matrix regulates Ca

Jing-Yi Jeng, Csaba Harasztosi, Adam J Carlton, Laura F Corns, Philine Marchetta, Stuart L Johnson, Richard J Goodyear, Kevin P Legan, Lukas Rüttiger, Guy P Richardson and 1 more

Open access · hybridAbstract read
In one paragraph

Article in The Journal of physiology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 20 papers.

0numbers the graph read from it
0cells of the map it votes in
20citing papers in PubMed
2.1field-weighted citation impact, top 14% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

20 citing papers in PubMed, 26 citations in OpenAlex.

  1. TECTB Variants Reveal Tectorial Membrane Vulnerability in Dominant Non-Syndromic Hearing Loss.Advanced science (Weinheim, Baden-Wurttemberg, Germany) · 2026
    Article
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  7. MYO7A is required for the functional integrity of the mechanoelectrical transduction complex in hair cells of the adult cochlea.Proceedings of the National Academy of Sciences of the United States of America · 2025
    Article
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  11. Types of Inheritance and Genes Associated with Familial Meniere Disease.Journal of the Association for Research in Otolaryngology : JARO · 2023
    Review
  12. Review
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  15. AAV-mediated rescue ofMolecular therapy. Methods & clinical development · 2022
    Article
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

11 authors at 3 institutions in 2 countries.

Jing-Yi JengDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Csaba HarasztosiDepartment of Otolaryngology Head & Neck Surgery, THRC, University of Tübingen, Tübingen, 72076, Germany.ORCID 0000-0002-9218-8690
Adam J CarltonDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.ORCID 0000-0002-1054-3901
Laura F CornsDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Philine MarchettaDepartment of Otolaryngology Head & Neck Surgery, THRC, University of Tübingen, Tübingen, 72076, Germany.
Stuart L JohnsonDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.
Richard J GoodyearSchool of Life Sciences, Falmer, University of Sussex, Brighton, BN1 9QG, UK.ORCID 0000-0001-6698-4127
Kevin P LeganSchool of Life Sciences, Falmer, University of Sussex, Brighton, BN1 9QG, UK.ORCID 0000-0002-7403-6415
Lukas RüttigerDepartment of Otolaryngology Head & Neck Surgery, THRC, University of Tübingen, Tübingen, 72076, Germany.ORCID 0000-0003-0015-0714
Guy P RichardsonSchool of Life Sciences, Falmer, University of Sussex, Brighton, BN1 9QG, UK.ORCID 0000-0001-8476-0223
Walter MarcottiDepartment of Biomedical Science, University of Sheffield, Sheffield, UK.ORCID 0000-0002-8770-7628
University of Sheffield · GBUniversity of Sussex · GBUniversity of Tübingen · DE

Funding

Wellcome Trust 087737Wellcome Trust 087737/Z/08/ZWellcome Trust 102892Wellcome Trust 102892/Z/13/Z
6 · The paper itself

Abstract

key pointsThe aim was to determine whether detachment of the tectorial membrane (TM) from the organ of Corti in Tecta/Tectb ABSTRACT: The tectorial membrane (TM) is an acellular structure of the cochlea that is attached to the stereociliary bundles of the outer hair cells (OHCs), electromotile cells that amplify motion of the cochlear partition and sharpen its frequency selectivity. Although the TM is essential for hearing, its role is still not fully understood. In Tecta/Tectb

Indexed as

StereociliaTectorial MembraneAnimalsExtracellular MatrixHair Cells, Auditory, OuterMiceOtoacoustic Emissions, SpontaneousTransducersadaptationcochleaelectrophysiologyendolymphatic calciumhair cellshearingmechanoelectrical transducter channeltectorial membrane

Identifiers

PMID33559882
PMCPMC7612128
OpenAlexW3126644913

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.