Evidence map›Paper›PMID 33559803›Full record

ArticleLasers in medical science2022

In vitro evaluation of physical and chemical parameters involved in aPDT of Aggregatibacter actinomycetemcomitans.

Gerdal Roberto de Sousa, Leandro O Soares, Betânia M Soares, Rosana de Carvalho Cruz, Paulo Uliana Junior, Thiago Santiago, Luiz M Farias, Paula Prazeres Magalhães, Lívio B Silveira, Luciana Almeida Lopes and 3 more

Abstract read
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Article in Lasers in medical science, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 4 papers.

0numbers the graph read from it
0cells of the map it votes in
4citing papers in PubMed
–field-weighted citation impact
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

4 citing papers in PubMed.

  1. Review
  2. Article
  3. Review
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4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors.

Gerdal Roberto de SousaBioengineering Laboratory, Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, MG, 31270-901, Belo Horizonte, Brazil. gerdalsousa@gmail.com.
Leandro O SoaresBioengineering Laboratory, Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, MG, 31270-901, Belo Horizonte, Brazil.
Betânia M SoaresBioengineering Laboratory, Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, MG, 31270-901, Belo Horizonte, Brazil.
Rosana de Carvalho CruzBioengineering Laboratory, Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, MG, 31270-901, Belo Horizonte, Brazil.
Paulo Uliana JuniorBioengineering Laboratory, Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, MG, 31270-901, Belo Horizonte, Brazil.
Thiago SantiagoBioengineering Laboratory, Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, MG, 31270-901, Belo Horizonte, Brazil.
Luiz M FariasLaboratory of Oral Microbiology and Anaerobes, Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Paula Prazeres MagalhãesLaboratory of Oral Microbiology and Anaerobes, Department of Microbiology, Institute of Biological Sciences, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.
Lívio B SilveiraBioengineering Laboratory, Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, MG, 31270-901, Belo Horizonte, Brazil.
Luciana Almeida LopesResearch and Education Center for Phototherapy in Health Sciences (NUPEN), São Carlos, SP, Brazil.
Marília Wellichan ManciniResearch and Education Center for Phototherapy in Health Sciences (NUPEN), São Carlos, SP, Brazil.
Rudolf HuebnerBioengineering Laboratory, Department of Mechanical Engineering, Universidade Federal de Minas Gerais, Av. Antônio Carlos, 6627, MG, 31270-901, Belo Horizonte, Brazil.
Marcus V L FerreiraFaculty of Dentistry, Universidade Federal de Minas Gerais, Belo Horizonte, MG, Brazil.

Funding

No grant is acknowledged in the PubMed record.

6 · The paper itself

Abstract

Periodontitis is an infectious disease characterized by the destruction of supporting tissues. Antimicrobial photodynamic therapy (aPDT) has been proposed as an improved method for eliminating microorganisms. Its efficiency depends on the correct use of physical and chemical parameters. Thus, these parameters and their relations were evaluated in this study with the purpose of establishing lethal conditions for combating bacterial agents. Diode lasers and light-emitting diodes (LEDs) were characterized to evaluate the absorption profile and resonance of methylene blue (MB) and toluidine blue O (TBO). The relations between light energy density and photosensitizer absorption were determined. Two methodologies were used to evaluate the effects of aPDT against Aggregatibacter actinomycetemcomitans. LED light exhibited a broad emission spectrum with a peak light wavelength of 637 nm and 99% purity. The resonance intensity of MB was higher with diode laser irradiation, and TBO showed higher resonance intensity with LED irradiation. There was no difference in the absorption profile of photosensitizers using diode lasers or LEDs, and variations in power density did not result in an increasing or decrease in light absorption. A. actinomycetemcomitans was susceptible to photodynamic processes. Emission spectra and peak light wavelengths of light sources combined with the absorption profiles of photosensitizers were the main parameters involved in determining the efficiency of photodynamic effects. Power density did not alter the light absorption of photosensitizers. The association between adequate irradiation characteristics and photosensitizer absorption results in complete inactivation of A. actinomycetemcomitans. In addition, the bactericidal effect was not altered by an increase in energy densities.

Indexed as

Anti-Infective AgentsPhotochemotherapyAggregatibacter actinomycetemcomitansPhotosensitizing AgentsTolonium ChlorideAnti-Infective AgentsPhotosensitizing AgentsTolonium ChlorideAggregatibacter actinomycetemcomitansDiode laserLEDMethylene blue (MB)Toluidine blue O (TBO)

Identifiers

PMID33559803

What OpenQuestion holds

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Registered trials

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Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.