Evidence map›Paper›PMID 33559374›Full record

ArticleArthritis & rheumatology (Hoboken, N.J.)2021

Aim2 Couples With Ube2i for Sumoylation-Mediated Repression of Interferon Signatures in Systemic Lupus Erythematosus.

Ailing Lu, Shuxian Wu, Junling Niu, Mengmeng Cui, Mengdan Chen, William L Clapp, Betsy J Barnes, Guangxun Meng

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Arthritis & rheumatology (Hoboken, N.J.), 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 5 papers.

0numbers the graph read from it
0cells of the map it votes in
5citing papers in PubMed
1.2field-weighted citation impact, top 22% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

5 citing papers in PubMed, 18 citations in OpenAlex.

  1. Review
  2. Review
  3. Article
  4. Review
  5. Article
4 · The record

Corrections and comments

5 · Who and what money

Authors and funding

8 authors at 4 institutions in 2 countries.

Ailing LuCenter for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Shanghai, China, and Center for Autoimmune Musculoskeletal and Hemaopoietic Diseases, Feinstein Institutes for Medical Research, Manhasset, New York.
Shuxian WuCenter for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, University of Chinese Academy of Sciences, Shanghai, China, and The Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China.
Junling NiuCenter for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, and the University of Chinese Academy of Sciences, Shanghai, China.
Mengmeng CuiCenter for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, and the University of Chinese Academy of Sciences, Shanghai, China.
Mengdan ChenCenter for Microbes, Development and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, and the University of Chinese Academy of Sciences, Shanghai, China.
William L ClappDepartment of Pathology, Immunology, and Laboratory Medicine, University of Florida, Gainesville.
Betsy J BarnesCenter for Autoimmune Musculoskeletal and Hematopoietic Disease, Feinstein Institutes for Medical Research, Manhasset, New York, and the Hofstra-Northwell Zucker School of Medicine, Hempstead, New York.
Guangxun MengCenter for Microbes, Development, and Health, Key Laboratory of Molecular Virology and Immunology, Institut Pasteur of Shanghai, Chinese Academy of Sciences, University of Chinese Academy of Sciences, Shanghai, China, The Joint Center for Infection and Immunity, Guangzhou Institute of Pediatrics, Guangzhou Women and Children's Medical Center, Guangzhou, China, and Pasteurien College, Soochow University, Suzhou, China.ORCID 0000-0003-4634-4661
Institut Pasteur of Shanghai · CNFeinstein Institute for Medical Research · USSoochow University · CNUniversity of Florida · US

Funding

IRF5 and Macrophage Activation Syndrome in systemic Juvenile Idiopathic ArthritisR01AR076242 · NIAMS · BENAROYA RESEARCH INST AT VIRGINIA MASON · PI BARNES, BETSY J, HAMERMAN, JESSICA A · 2019 to 2023
$3.3M
NIAMS NIH HHS R01 AR076242
6 · The paper itself

Abstract

objectiveSystemic lupus erythematosus (SLE) involves kidney damage, and the inflammasome-caspase-1 axis has been demonstrated to promote renal pathogenesis. The present study was designed to explore the function of the Absent in Melanoma 2 (Aim2) protein in SLE.

methodsFemale wild-type Aim2

resultsThe absence of Aim2, but not Asc, led to enhanced SLE in mice that received pristane treatment. Increased immune cell infiltration and type I interferon (IFN) signatures in the kidneys of Aim2

conclusionThe present study demonstrates a critical role for Aim2 in an optimal Ube2i-mediated sumoylation-based suppression of type I IFN generation and development of SLE. As such, the Aim2-Ube2i axis can thus be a novel target for intervention in SLE.

Indexed as

AnimalsDisease Models, AnimalDNA-Binding ProteinsFemaleInterferon Type ILupus Erythematosus, SystemicMiceSumoylationTerpenesUbiquitin-Conjugating EnzymesUbiquitin-Conjugating Enzyme UBC9Aim2 protein, mouseDNA-Binding ProteinsInterferon Type IpristaneTerpenesUbiquitin-Conjugating EnzymesUbiquitin-Conjugating Enzyme UBC9

Identifiers

PMID33559374
PMCPMC8324518
OpenAlexW3127042546

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.