Evidence map›Paper›PMID 33559355›Full record

ArticleEarly intervention in psychiatry2022

Social impairment in relation to clinical symptoms in youth at high risk for bipolar disorder.

Marc J Weintraub, Danielle Keenan-Miller, Christopher D Schneck, Marcy Forgey Borlik, Robert L Suddath, Sarah E Marvin, Manpreet K Singh, Kiki D Chang, David J Miklowitz

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Early intervention in psychiatry, 2022. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 1 paper.

0numbers the graph read from it
0cells of the map it votes in
1citing papers in PubMed
0.3field-weighted citation impact, top 46% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

1 citing paper in PubMed, 4 citations in OpenAlex.

  1. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 1 country.

Marc J WeintraubSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.ORCID 0000-0001-8724-120X
Danielle Keenan-MillerDepartment of Psychology, University of California, Los Angeles, California, USA.
Christopher D SchneckDepartment of Psychiatry, University of Colorado Anschutz Medical Campus, Aurora, Colorado, USA.
Marcy Forgey BorlikSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
Robert L SuddathSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
Sarah E MarvinSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
Manpreet K SinghDepartment of Psychiatry and Behavioral Sciences, Stanford University School of Medicine, Stanford, California, USA.
Kiki D ChangPrivate Practice, Palo Alto, California, USA.
David J MiklowitzSemel Institute for Neuroscience and Human Behavior, University of California, Los Angeles, California, USA.
University of California, Los Angeles · USPalo Alto Institute · USStanford University · USUniversity of Colorado Anschutz Medical Campus · US

Funding

Family-Focused Therapy for Individuals at High Clinical Risk for Psychosis: A Confirmatory Efficacy TrialR01MH123575 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI BEARDEN, CARRIE E, MIKLOWITZ, DAVID JAY · 2020 to 2023
$5.4M
1/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093676 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI MIKLOWITZ, DAVID JAY · 2012 to 2016
$3.6M
Neurodevelopment and Psychosis in the 22q11.2 Copy Number VariantsR37MH085953 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI CARRIE E BEARDEN · 2023 to 2026
$2.9M
2/2-Early Intervention for Youth at Risk for Bipolar DisorderR01MH093666 · NIMH · STANFORD UNIVERSITY · PI HARDAN, ANTONIO · 2012 to 2016
$2.0M
Technology-Enhanced Family-Focused Treatment for Adolescents at High Risk for Mood DisordersR34MH117200 · NIMH · UNIVERSITY OF CALIFORNIA LOS ANGELES · PI AREVIAN, ARMEN C, MIKLOWITZ, DAVID JAY · 2018 to 2020
$933k
Family-Focused Therapy as Early Treatment for Youth at Risk for Bipolar DisorderR34MH077856 · NIMH · UNIVERSITY OF COLORADO · PI MIKLOWITZ, DAVID JAY · 2007 to 2009
$638k
NIMH NIH HHS R01 MH093666NIMH NIH HHS R01 MH093676NIMH NIH HHS R01 MH123575NIMH NIH HHS R34 MH077856NIMH NIH HHS R34 MH117200NIMH NIH HHS R37 MH085953
6 · The paper itself

Abstract

aimSocial impairment is common in individuals with bipolar disorder (BD), although its role in youths at high-risk for BD (i.e., mood symptoms in the context of a family history of BD) is not well understood. Social impairment takes many forms including social withdrawal, relational aggression, physical aggression, and victimization. The aim of this study was to explore the links between social impairment and clinical symptoms in youth at high-risk for BD.

methodsThe sample included 127 youths with elevations in mood symptoms (depression or hypomania) and at least one first and/or second degree relative with BD. Measures of youths' current psychopathology (i.e., depressive and manic severity, suicidality, anxiety, and attention-deficit/hyperactivity disorder [ADHD]) were regressed onto youths' self-reports of social impairment (i.e., social withdrawal, relational aggression, physical aggression, and victimization).

resultsDepressive symptoms, suicidal ideation, and anxiety symptoms were related to social withdrawal. Suicidal ideation was also related to reactive aggression. ADHD symptoms related to reactive and proactive aggression as well as relational victimization. Manic symptoms were not associated with social impairment in this sample.

conclusionsAlthough cross-sectional, study findings point to potential treatment targets related to social functioning. Specifically, social withdrawal should be a target for treatment of childhood depressive and anxiety symptoms. Treatments that focus on social skills and cognitive functioning deficits associated with BD may also have clinical utility.

Indexed as

Attention Deficit Disorder with HyperactivityBipolar DisorderAdolescentAnxietyAnxiety DisordersCross-Sectional StudiesHumansadolescentclinical characteristicspaediatricpeersocial functioning

Identifiers

PMID33559355
PMCPMC8492196
OpenAlexW3128389161

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.