Evidence map›Paper›PMID 33559045›Full record

ArticlePharmaceutical research2021

Influence of Cation Transporters (OCTs and MATEs) on the Renal and Hepatobiliary Disposition of [

Irene Hernández-Lozano, Severin Mairinger, Michael Sauberer, Johann Stanek, Thomas Filip, Thomas Wanek, Giuliano Ciarimboli, Nicolas Tournier, Oliver Langer

Open access · hybridAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Pharmaceutical research, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 2 papers.

0numbers the graph read from it
0cells of the map it votes in
2citing papers in PubMed
0.1field-weighted citation impact, top 57% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

2 citing papers in PubMed, 2 citations in OpenAlex.

  1. Designing a Small Molecule for PET Radiotracing: [Molecules (Basel, Switzerland) · 2025
    Review
  2. Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

9 authors at 4 institutions in 3 countries.

Irene Hernández-LozanoDepartment of Clinical Pharmacology, Medical University of Vienna, A-1090, Vienna, Austria.
Severin MairingerPreclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
Michael SaubererPreclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
Johann StanekPreclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
Thomas FilipPreclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
Thomas WanekPreclinical Molecular Imaging, AIT Austrian Institute of Technology GmbH, Seibersdorf, Austria.
Giuliano CiarimboliMedicine Clinic D. Experimental Nephrology, University Hospital Münster, Münster, Germany.
Nicolas TournierLaboratoire d'Imagerie Biomédicale Multimodale (BioMaps), CEA, CNRS, Inserm, Service Hospitalier Frédéric Joliot, Université Paris-Saclay, Orsay, France.
Oliver LangerDepartment of Clinical Pharmacology, Medical University of Vienna, A-1090, Vienna, Austria. oliver.langer@meduniwien.ac.at.ORCID http://orcid.org/0000-0002-4048-5781
Austrian Institute of Technology · ATCentre National de la Recherche Scientifique · FRMedical University of Vienna · ATUniversity Hospital Münster · DE

Funding

Austrian Science Fund KLI 694-B30Austrian Science Fund FWF KLI 694
6 · The paper itself

Abstract

purposeTo investigate the role of cation transporters (OCTs, MATEs) in the renal and hepatic disposition of the radiolabeled antiemetic drug [

methodsPET was performed in wild-type mice after administration of an intravenous microdose (<1 μg) of [

results[

conclusionsOur results suggest a contribution of OCT1/2 to the kidney and liver uptake and of MATEs to the urinary excretion of [

Indexed as

Hepatobiliary EliminationRenal EliminationAnimalsCatecholamine Plasma Membrane Transport ProteinsFemaleHEK293 CellsHumansMaleMetoclopramideMiceMice, KnockoutModels, AnimalOrganic Cation Transporter 2Catecholamine Plasma Membrane Transport ProteinsMetoclopramideOrganic Cation Transporter 2Slc22a1 protein, mouseSlc22a2 protein, mouse[11C]metoclopramideCYP2D6multidrug and toxin extrusion proteins (MATEs)organic cation transporters (OCTs)positron emission tomography (PET)

Identifiers

PMID33559045
PMCPMC7902338
OpenAlexW3128408154

What OpenQuestion holds

Textmetadata
LicenceCC BY
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.