Evidence map›Paper›PMID 33559035›Full record

ArticleMolecular imaging and biology2021

Synthesis and Characterization of [

Gengyang Yuan, Nicolas J Guehl, Baohui Zheng, Xiying Qu, Sung-Hyun Moon, Maeva Dhaynaut, Timothy M Shoup, Sepideh Afshar, Hye Jin Kang, Zhaoda Zhang and 3 more

Open access · greenAbstract read
PubMed Full text at PMC Publisher
In one paragraph

Article in Molecular imaging and biology, 2021. The graph could read no effect estimate from its abstract, so it casts no vote on the map. Cited by 7 papers.

0numbers the graph read from it
0cells of the map it votes in
7citing papers in PubMed
1.4field-weighted citation impact, top 21% of its field
1 · What the graph read from it

What it found

Each row is one number read from the abstract, on the scale the paper reported it, with its interval. Left of the dashed line favours the treatment, right favours the comparator. Under each row is the sentence it came from. New to these charts? A ten-minute tutorial.

The abstract states no effect estimate the extractor could read, or names no intervention and outcome on the map, so this paper lights no cell and moves no belief. It is still indexed, cited and linked below.

2 · The registry

The trial behind it

Trials whose registry record cites this paper, or whose number appears in the abstract. A trial that started after this paper was published is citing it as background, not reporting it.

Neither the registry nor the abstract names a trial number. If this is a trial report, that itself is worth knowing.

3 · Its place in the literature

Who cites it

7 citing papers in PubMed, 15 citations in OpenAlex.

  1. Article
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  3. Distribution of [Naunyn-Schmiedeberg's archives of pharmacology · 2023
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  4. PET imaging studies to investigate functional expression of mGluR2 using [Journal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and Metabolism · 2023
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  5. Design, Synthesis, and Characterization of [Journal of medicinal chemistry · 2022
    Article
  6. Synthesis and Characterization of 5-(2-Fluoro-4-[Journal of medicinal chemistry · 2022
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  7. SThe Journal of organic chemistry · 2021
    Article
4 · The record

Corrections and comments

PubMed lists nothing against this paper. Absence here is not a guarantee, only a check that was made.

5 · Who and what money

Authors and funding

13 authors at 2 institutions in 1 country.

Gengyang YuanGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA. gyyuan@mgh.harvard.edu.ORCID 0000-0003-4817-0052
Nicolas J GuehlGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA.
Baohui ZhengGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA.
Xiying QuGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA.
Sung-Hyun MoonGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA.
Maeva DhaynautGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA.
Timothy M ShoupGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA.
Sepideh AfsharGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA.
Hye Jin KangDepartment of Pharmacology, University of North Carolina Chapel Hill School of Medicine, Chapel Hill, NC, 27514, USA.
Zhaoda ZhangAthinoula A. Martinos Center for Biomedical Imaging, Massachusetts General Hospital and Harvard Medical School, 149 Thirteenth Street, Suite 2301, Charlestown, MA, 02129, USA.
Georges El FakhriGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA.
Marc D NormandinGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA.
Anna-Liisa BrownellGordon Center for Medical Imaging, Massachusetts General Hospital and Harvard Medical School, 3rd Avenue, Charlestown, MA, 02129, USA. abrownell@mgh.harvard.edu.ORCID 0000-0002-3814-868X
Harvard University · USUniversity of North Carolina at Chapel Hill · US

Funding

Unified Joint Statistical Reconstruction of PET & MRP41EB022544 · NIBIB · YALE UNIVERSITY · PI Georges El Fakhri · 2017 to 2026
$14.8M
Positive Allosteric Modulators as PET Imaging Ligans for mGluR4R01NS100164 · NINDS · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA, ZHANG, ZHAODA · 2016 to 2020
$3.7M
Designing group specific PET ligands for mGluR2R01EB021708 · NIBIB · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA, ZHANG, ZHAODA · 2016 to 2019
$2.2M
Electronics Upgrade for 11.7 TS10OD025234 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI CARAVAN, PETER D · 2018 to 2018
$595k
F-18 SynthesizerS10RR023452 · NCRR · MASSACHUSETTS GENERAL HOSPITAL · PI BROWNELL, ANNA-LIISA · 2007 to 2007
$500k
Gamma counter and continuous blood sampler for quantitative PET imagingS10OD018035 · OD · MASSACHUSETTS GENERAL HOSPITAL · PI EL FAKHRI, GEORGES, NORMANDIN, MARC DAVID · 2014 to 2014
$144k
NCRR NIH HHS S10 RR023452NIBIB NIH HHS P41 EB022544NIBIB NIH HHS R01 EB021708NIH HHS S10 OD018035NIH HHS S10 OD025234NINDS NIH HHS R01 NS100164
6 · The paper itself

Abstract

purposeMetabotropic glutamate receptor 2 (mGluR2) has been implicated in various psychiatric and neurological disorders, such as schizophrenia and Alzheimer's disease. We have previously developed [ PROCEDURES: JNJ-46356479 (8) was radiolabeled via the copper (I)-mediated radiofluorination of organoborane 9. In vivo PET imaging experiments with [

resultsJNJ-46356479 (8) exhibited excellent selectivity against other mGluRs. In vivo PET imaging studies showed reversible and specific binding characteristic of [

conclusions[

Indexed as

AnimalsBrainFluorodeoxyglucose F18LigandsMacaca fascicularisMaleMiceMice, Inbred C57BLRadiopharmaceuticalsRatsRats, Sprague-DawleyReceptors, Metabotropic GlutamateTissue DistributionFluorodeoxyglucose F18Ligandsmetabotropic glutamate receptor 2RadiopharmaceuticalsReceptors, Metabotropic GlutamateKinetic modelingmGluR2Neurological diseasesNon-human primatePETRodents

Identifiers

PMID33559035
PMCPMC8277681
OpenAlexW3126665290

What OpenQuestion holds

Textmetadata
LicenceTDM
Read underepoch 390

Registered trials

None linked

Read under generation 80e0d062 · epoch 390. Bibliography from PubMed, PubMed Central and OpenAlex; grants from NIH RePORTER; trial links from ClinicalTrials.gov; estimates, votes and beliefs from the OpenQuestion graph.